All Rankings

Top 100 Biotech Startups in San Francisco 2026

The most-funded biotechnology and genomics startups headquartered in San Francisco and South San Francisco, the Bay Area's biotech hub, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $23.2B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Biotech,Genomics&countries=United+States&cities=San+Francisco,South+San+Francisco&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

51
Character Bio

Precision medicine biotech using genomics, clinical data, and AI to discover therapies for progre...

San Francisco, United States11–50Artificial Intelligence, Biotech
Extension RoundTotal funding$110.0MSep 2025
52
MISSION BIO INC

R&D company with 7 SBIR/STTR awards from Department of Health and Human Services, National Scienc...

South San Francisco, United States1–10Biotech, Healthcare
Venture RoundTotal funding$110.0MAug 2025
53
Checkerspot, Inc.

Checkerspot designs high performance materials at a molecular level with technology at the nexus ...

San Francisco, United States11–50Food & Beverage, Biotech
Series CTotal funding$109.0MFeb 2023
54
Ethyreal Bio

Biotech developing ETHY-001, a best-in-class anti-TSHR antibody targeting root causes of Graves' ...

San Francisco, United States1–10Biotech, Healthcare
SeedTotal funding$101.0MJun 2026
55
Trace Neuroscience

Biopharmaceutical company developing genomic medicine for ALS, focused on UNC13A restoration as a...

South San Francisco, United StatesBiotech
Series ATotal funding$101.0MNov 2024
56
Vial

Next-generation pharma company using computationally designed therapeutics and automated clinical...

San Francisco, United States51–200Life Sciences, Biotech
Series BTotal funding$101.0MNov 2022
57
NantOmics

Molecular diagnostics company providing panomic cancer profiling — combining DNA sequencing, RNA ...

San Francisco, United States11–50Biotech, Healthcare
Venture RoundTotal funding$100.0MJan 2016
58
GOOD Meat

Cultivated meat brand under Eat Just; the first company to receive government approval to sell ce...

San Francisco, United States51–200Biotech, Climate Tech
Series ATotal funding$97.0MSep 2021
59
Prolific Machines

Prolific Machines integrates optogenetic cell line development and illumination systems to give m...

San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$97.0MJun 2024
60
Brightseed

AI-powered bioactives discovery platform that helps health science teams discover, validate, and ...

San Francisco, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$95.0MMay 2022
61
Perceive Bio

Gene therapy biotech advancing treatments for ophthalmology conditions including macular degenera...

South San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$93.0MJan 2026
62
Centivax

Centivax is a clinical-stage company developing broad-spectrum vaccines, with its first universal...

San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$92.0MMar 2026
63
Gigagen, Inc.

R&D company with 6 SBIR/STTR awards from Department of Health and Human Services.

South San Francisco, United States1–10Biotech, Genomics
Corporate RoundTotal funding$90.0MMar 2021
64
Infinimmune

Infinimmune discovers and engineers antibodies already proven in people, then advances these huma...

South San Francisco, United States1–10Biotech, Healthcare
Series ATotal funding$87.0MAug 2026
65
Nitrase Therapeutics

Protein nitrosylation platform for cancer and inflammation

South San Francisco, United States11–50Biotech, Healthcare
Series ATotal funding$83.0MApr 2024
66
Mendra

Biopharmaceutical company using AI to accelerate the acquisition, development, and commercializat...

San Francisco, United States1–10Artificial Intelligence, Biotech
Series ATotal funding$82.0MJan 2026
67
Alpine Bio

Genetically engineered plant-based biomanufacturing platform, starting with plant-based cheese

San Francisco, United States51–200Healthcare, Biotech
Series BTotal funding$75.0MJul 2021
68
Edison Scientific

AI platform for scientific discovery enabling researchers to complete literature synthesis, data ...

San Francisco, United States11–50Artificial Intelligence, Deep Tech
SeedTotal funding$70.0MDec 2025
69
Prolynx

Prolynx develops extended-duration therapeutics for obesity and related metabolic diseases, desig...

San Francisco, United States1–10Biotech
Series ATotal funding$70.0MNov 2025
70
Helicore Biopharma

Helicore Bio develops long-acting antibody-peptide conjugates that deliver quarterly therapies fo...

South San Francisco, United States1–10Biotech
Series ATotal funding$65.0MJan 2025
71
Vicinitas Therapeutics

Vicinitas Therapeutics is a biotech company developing targeted protein stabilizers known as Deub...

South San Francisco, United States11–50Biotech, Healthcare
Series ATotal funding$65.0MJul 2022
72
Medra

Physical AI platform building autonomous robotic scientists that conduct biological experiments t...

San Francisco, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$63.0MDec 2025
73
89bio

Biopharmaceutical company focused on nonalcoholic steatohepatitis (NASH) and other liver and meta...

San Francisco, United States11–50Biotech, Healthcare
Series ATotal funding$60.0MOct 2018
74
NOCTRIX HEALTH, INC.

Noctrix Health develops clinically validated wearable therapeutics to help people manage chronic ...

San Francisco, United States1–10Biotech, Healthcare
Series CTotal funding$59.7MJan 2024
75
Evvy

At-home vaginal microbiome testing and care platform offering metagenomic sequencing, clinician-r...

San Francisco, United States11–50Life Sciences, Biotech
Series BTotal funding$59.0MSep 2026