All Rankings

Top 100 Biotech Startups in San Francisco 2026

The most-funded biotechnology and genomics startups headquartered in San Francisco and South San Francisco, the Bay Area's biotech hub, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $23.2B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Biotech,Genomics&countries=United+States&cities=San+Francisco,South+San+Francisco&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

76
Prellis

Prellis combines bioprinted lymph node organoids with machine learning to discover antibody thera...

San Francisco, United States11–50Healthcare, Biotech
Series CTotal funding$58.2MAug 2022
77
Until Labs

Until Labs develops reversible cryopreservation systems for human organs to solve the donor organ...

San Francisco, United States51–200Biotech, Healthcare
Series ATotal funding$58.0MJan 2025
78
Pendulum

Pendulum is a biotechnology company working to improve the human microbiome.

San Francisco, United States51–200Biotech, Healthcare
Venture RoundTotal funding$57.0MFeb 2025
79
VectorBuilder, Inc.

VectorBuilder is a Leading Provider of Recombinant Vectors and Viruses, Offering a Wide Range Gen...

San Francisco, United States501–1000Biotech
Venture RoundTotal funding$57.0MJul 2023
80
Blade Therapeutics

Oral small-molecule therapies for fibrosis and neurodegenerative diseases

South San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$55.0MJun 2016
81
Switch Therapeutics

A preclinical stage biotechnology company pioneering a new way to use RNA science to treat diseases

South San Francisco, United States11–50Life Sciences, Biotech
Series ATotal funding$52.0MMar 2023
82
Radical Numerics

AI research lab building general biological intelligence models trained on DNA, RNA, and protein ...

San Francisco, United States11–50Artificial Intelligence, Biotech
SeedTotal funding$50.0MJun 2026
83
BlueLight Therapeutics

Structure-function approach for challenging drug targets (formerly Biodesy)

South San Francisco, United States11–50Biotech, Healthcare
Series CTotal funding$45.0MSep 2018
84
Coherence Neuro

Therapeutic neurotechnology company developing brain-computer interface systems to monitor and tr...

San Francisco, United States11–50Biotech, Medical Devices
Series ATotal funding$45.0MOct 2026
85
Klyne

The next generation of in-silico drug discovery tools

San Francisco, United States1–10Artificial Intelligence, Biotech
Venture RoundTotal funding$45.0MJan 2023
86
Aizon

AI SaaS platform for pharmaceutical and biotech manufacturing operations.

San Francisco, United States51–200Artificial Intelligence, Healthcare
Series CTotal funding$43.5MFeb 2024
87
Atomic AI

Atomic AI applies machine learning and structural biology to design highly selective small-molecu...

San Francisco, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$42.0MJan 2023
88
Tahoe Therapeutics

AI-powered biotechnology company building virtual cell models and gigascale single-cell datasets ...

South San Francisco, United States11–50Life Sciences, Artificial Intelligence
Venture RoundTotal funding$42.0MAug 2025
89
3T Biosciences

Immunotherapy company developing next-generation TCR-based therapeutics for cancer treatment.

South San Francisco, United States11–50Biotech, Therapeutics
Series ATotal funding$40.0MAug 2022
90
TenSixteen Bio

Precision platform therapeutics company targeting somatic mosaicism and DNA changes across multip...

San Francisco, United States1–10Biotech, Genomics
Series ATotal funding$40.0MJan 2022
91
Mantra Bio

Biotechnology company developing targeted exosome-based therapeutics using its proprietary REVEAL...

South San Francisco, United States11–50Biotech, Drug Discovery
Series ATotal funding$39.0MJan 2023
92
Lygos

Lygos engineers yeast to convert sugar into high-value industrial…

San Francisco, United States51–200Biotech, Climate Tech
Venture RoundTotal funding$38.6MJan 2019
93
Mindstate Design Labs

Next-generation psychedelic therapeutics for mental health

San Francisco, United States1–10Artificial Intelligence, Biotech
Venture RoundTotal funding$37.2MNov 2024
94
Spiral TX

Spiral Therapeutics develops a minimally invasive drug delivery platform to treat inner ear disor...

South San Francisco, United States1–10Biotech, Therapeutics
Series BTotal funding$35.3MApr 2026
95
Permanence Bio

Permanence Bio develops medicines to shield DNA from damage behind aging, disease, and cancer, us...

San Francisco, United States1–10Biotech, Drug Discovery
Series ATotal funding$35.0MJan 2026
96
Latch Bio

Data platform providing reproducible analysis workflows and developer tools to biopharma, R&D lab...

San Francisco, United States11–50Biotech, Data & Analytics
Series ATotal funding$33.0MMay 2022
97
Nodexus

Nodexus is democratizing access to live single cells for applications including gene editing, dru...

San Francisco, United States11–50Healthcare, Biotech
Series ATotal funding$31.8MDec 2021
98
OneSkin

OneSkin develops skin health products using its OS-01 peptide to target cellular senescence and s...

San Francisco, United States11–50Biotech, Healthcare
Series ATotal funding$30.6MAug 2025
99
Weave Bio

Weave connects source data, documents, and teams in real time, carrying regulatory context forwar...

San Francisco, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$30.0MOct 2025
100
Montara Therapeutics

Montara Therapeutics develops therapies for patients with neurological diseases, using its BrainO...

San Francisco, United States11–50Biotech, Healthcare
Extension RoundTotal funding$28.0MMar 2025