Prolific Machines

Prolific Machines is a biotechnology company pioneering optogenetic cell line development and AI-driven bioprocess optimization for biopharmaceutical manufacturing. The company's Photomolecular platform uses light to precisely control gene expression in mammalian cell lines, enabling up to 5-fold increases in therapeutic protein titers and unlocking production of difficult-to-express biotherapeutics including antibodies, biosimilars, and multispecific proteins. By decoupling cell growth from protein production through light-mediated control, Prolific addresses key challenges in biomanufacturing cost, consistency, and scalability. The platform is cell-line agnostic and adaptable to any bioreactor, positioning it as an infrastructure layer for next-generation biologics production.