Top Series A Companies in the US 2026

Series A companies headquartered in the United States — the most promising US growth-stage startups that have cleared the first major institutional bar.

As of August 2026, these 100 companies have raised $28.4B in combined funding.

Showing top 100 of 3,322 matching companies · Ranked by total funding raised · Updated Aug 2026

1

Biotech advancing cellular rejuvenation programming to restore cell health and reverse disease.

San Francisco, United States501–1000Life Sciences, Biotech

Series A·$3.0B·Jan 2022

2

E-commerce marketplace platform.

Riyadh, United States5001–10000E-Commerce

Series A·$2.0B·May 2026

3

Scientific superintelligence platform building autonomous AI labs for life, chemical, and materia...

Cambridge, United States51–200Artificial Intelligence, Biotech

Series A·$1.3B·Jun 2026

4

World Labs is a spatial intelligence AI company building Large World Models (LWMs) to perceive, g...

San Francisco, United States11–50Artificial Intelligence, Infrastructure

Series A·$1.2B·Feb 2026

5

Pacific Fusion was founded in 2023 to develop pulsed magnetic inertial fusion for abundant, affor...

Fremont, United States51–200Energy

Series A·$900.0M·Oct 2024

6

Nuclear energy startup building hundreds of reactors at one Gigasite for heavy industrial power a...

El Segundo, United States11–50Climate Tech, Defense Tech

Series A·$729.0M·May 2026

7

Beeline Medicines

Clinical-stage biotechnology company developing precision therapies for autoimmune diseases.

Boston, United StatesBiotech, Healthcare

Series A·$726.3M·Jul 2026

8

Seamlessly contextualize your customer's issue into a perfectly packaged service ticket deliverin...

San Francisco, United States1–10Retail, Artificial Intelligence

Series A·$703.5M·May 2026

9

Preventive health and longevity clinic offering 30+ advanced diagnostics in a single day to detec...

San Francisco, United States11–50Healthcare, Preventive Medicine

Series A·$559.0M·Jan 2025

10

MoonPay is the leading on-ramp for crypto, allowing consumers to create a Web3 passport and pay f...

Miami, United States201–500Crypto & Web3, Fintech

Series A·$555.0M·Nov 2021

11

Transmit Security

Transmit Security is an identity access management vendor offering identity orchestration and aut...

Tel Aviv, United States201–500Financial Services, Cybersecurity

Series A·$543.0M·Jun 2021

12

Inertia is a commercial fusion energy company.

Livermore, United States11–50Clean Energy, Deep Tech

Series A·$450.0M·Feb 2026

13

Palo Alto, California-based robotics startup that emerged from stealth

Palo Alto, United States11–50Robotics

Series A·$450.0M·Mar 2026

14

Aptos is a Web3 startup that builds a scalable layer 1 blockchain.

Palo Alto, United States51–200Crypto & Web3, Developer Tools

Series A·$350.0M·Jul 2022

15

Digital bank for startups and cryptocurrency companies, founded by Palmer Luckey, targeting the g...

Columbus, United States51–200Fintech

Series A·$350.0M·Dec 2025

16

Ricursive Intelligence

Ricursive builds the AI stack that designs, verifies and closes silicon.

Palo Alto, United States1–10Artificial Intelligence, Semiconductors

Series A·$335.0M·Mar 2026

17

Nitra offers a simpler, smarter way for healthcare practices to manage their spending and create ...

New York, United States11–50Fintech, Healthcare

Series A·$321.0M·Mar 2026

18

Laser-driven fusion energy company building on NIF's foundation to develop clean, abundant fusion...

Darmstadt, United States51–200Climate Tech

Series A·$319.0M·Jun 2026

19

Generative AI platform for creators and social media teams to create and edit images, videos, and...

San Francisco, United States51–200Generative AI, Media

Series A·$310.0M·Mar 2026

20

Biopharmaceutical company focusing on pre-clinical and early-stage clinical programs for genetic ...

Palo Alto, United States11–50Biotech, Healthcare

Series A·$300.0M·Aug 2024

21

Neutral-atom quantum computing startup.

Pasadena, United States11–50Quantum Computing

Series A·$300.0M·Jul 2026

22

healthcare startup that raised over $100M in 2023

Irving, United States1001–5000Healthcare

Series A·$300.0M·Jan 2023

23

YC-backed startup building quantum-accelerated AI servers combining multiple qubit types to speed...

San Francisco, United States1–10Artificial Intelligence, Hardware Infrastructure

Series A·$278.0M·Apr 2026

24

Orbital Therapeutics

RNA (incl circular RNA) medicines for in vivo cellular reprogramming

Cambridge, United States51–200Healthcare

Series A·$270.0M·Apr 2023

25

Telly offers the first Dual Screen Smart TV.

San Francisco, United States51–200Adtech, Hardware

Series A·$270.0M·Aug 2024

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