All Rankings

Top 100 Biotech Startups in San Francisco 2026

The most-funded biotechnology and genomics startups headquartered in San Francisco and South San Francisco, the Bay Area's biotech hub, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $23.2B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Biotech,Genomics&countries=United+States&cities=San+Francisco,South+San+Francisco&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

1
Altos Labs

Altos Labs combines academic science and industry development to create medicines that restore ce...

San Francisco, United States501–1000Life Sciences, Biotech
Series ATotal funding$3.0BJan 2022
2
Calico

Calico researches human aging using advanced technologies and model systems, applying that knowle...

South San Francisco, United States201–500Biotech, Healthcare
Corporate RoundTotal funding$2.3BJun 2018
3
Xaira Therapeutics

Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intellig...

South San Francisco, United States51–200Artificial Intelligence, Biotech
Series ATotal funding$1.0BApr 2024
4
ArsenalBio

Clinical-stage programmable cell therapy company developing engineered T-cell therapies for solid...

San Francisco, United States201–500Biotech, Life Sciences
Series CTotal funding$955.0MSep 2024
5
Cellares

Cellares develops and operates automated smart factories that manufacture cell therapies for biot...

South San Francisco, United States51–200Biotech, Healthcare
Series DTotal funding$939.0MJun 2026
6
NewLimit

NewLimit develops medicines that unlock cellular regenerative potential to extend human healthspa...

South San Francisco, United States11–50Biotech, Healthcare
Venture RoundTotal funding$735.0MJun 2026
7
insitro

High-quality perturbational data generation and AI to discover new targets and enable drug discov...

South San Francisco, United States201–500Artificial Intelligence, Healthcare
Series CTotal funding$643.0MMar 2021
8
Chai Discovery

Chai Discovery builds frontier AI to predict and reprogram interactions between biochemical molec...

San Francisco, United States11–50Artificial Intelligence, Biotech
Series CTotal funding$630.0MJul 2026
9
Freenome

Freenome develops blood-based cancer screening tests using computational biology, machine learnin...

South San Francisco, United States501–1000Artificial Intelligence, Biotech
Series ETotal funding$554.0MFeb 2024
10
Encoded Therapeutics

Gene therapy company developing precision gene therapies for debilitating neurological disorders,...

South San Francisco, United States51–200Biotech, Therapeutics
Series FTotal funding$514.0MSep 2026
11
Owkin

Owkin builds agentic AI scientists trained on multimodal patient data to help biopharma teams acc...

San Francisco, United States201–500Artificial Intelligence, Biotech
Corporate RoundTotal funding$445.2MJan 2023
12
Benchling

Benchling provides a cloud platform for life sciences R&D, helping scientific teams plan experime...

San Francisco, United States501–1000Biotech, SaaS
Series G+Total funding$412.0MNov 2021
13
Tizona Therapeutics

Tizona Therapeutics translates novel scientific insights into first-in-class immunotherapies desi...

South San Francisco, United States11–50Biotech, Healthcare
Corporate RoundTotal funding$370.0MJul 2020
14
Terremoto Biosciences

Clinical-stage biotech company using covalent chemistry to develop small molecule medicines for o...

South San Francisco, United States51–200Biotech
Series CTotal funding$358.0MJan 2025
15
Nature's Fynd

Nature's Fynd makes nutritious fungi-based meat and dairy alternatives using Fy protein, born fro...

San Francisco, United States51–200consumer packaged goods, Biotech
Series CTotal funding$350.0MJul 2021
16
Ohalo Genetics

Ohalo Genetics develops advanced breeding systems and improved plant varieties that help farmers ...

South San Francisco, United States51–200Agtech, Biotech
Series CTotal funding$317.3MFeb 2025
17
Lycia Therapeutics

Lycia develops LYTAC therapeutics that transport disease-causing extracellular proteins into cell...

South San Francisco, United States11–50Biotech, Healthcare
Series DTotal funding$301.6MJun 2026
18
Soley Therapeutics

Soley Therapeutics uses cellular stress sensing, proprietary imaging, automation, and AI to disco...

South San Francisco, United States11–50Artificial Intelligence, Biotech
Series CTotal funding$295.0MJan 2026
19
AltruBio

AltruBio develops safer, more durable therapeutics for immunological diseases, targeting unmet ne...

San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$288.0MMay 2024
20
Expedition Therapeutics

Clinical-stage biotech advancing a Phase 2 COPD therapy.

San Francisco, United States1–10Biotech, Healthcare
Series BTotal funding$280.0MAug 2026
21
Electra Therapeutics

Clinical-stage biotech developing SIRP-targeting therapies for autoimmune diseases and cancer wit...

South San Francisco, United States11–50Biotech, Healthcare
Series CTotal funding$267.0MOct 2025
22
Frontier Medicines

Clinical-stage precision-medicine biotech using chemoproteomics and AI to discover covalent small...

San Francisco, United States51–200Biotech, Drug Discovery
Extension RoundTotal funding$255.5MJun 2024
23
InterVenn

Life science company using AI-powered glycoproteomics to decode glycosylated proteins for disease...

South San Francisco, United States51–200Artificial Intelligence, Biotech
Series CTotal funding$253.8MAug 2021
24
Vir

Clinical-stage biopharmaceutical company leveraging the immune system to develop medicines for in...

San Francisco, United States201–500Biotech, Healthcare
Growth EquityTotal funding$250.0MOct 2024
25
Osanni Bio

San Francisco therapeutics company using a biodesign-driven innovation engine to discover ophthal...

San Francisco, United States11–50Biotech, Healthcare
Venture RoundTotal funding$230.0MJun 2026