All Rankings

Top 100 Biotech Startups in San Francisco 2026

The most-funded biotechnology and genomics startups headquartered in San Francisco and South San Francisco, the Bay Area's biotech hub, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $23.2B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Biotech,Genomics&countries=United+States&cities=San+Francisco,South+San+Francisco&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

26
Atomwise

AI-native drug discovery company, now operating as Numerion Labs, that uses machine learning to e...

San Francisco, United States51–200Biotech, Artificial Intelligence
Series CTotal funding$219.0MMar 2024
27
TRexBio

TRexBio develops immunoregulatory medicines for autoimmune and inflammatory diseases, using human...

South San Francisco, United States11–50Biotech, Healthcare
Extension RoundTotal funding$219.0MJan 2026
28
STAR Therapeutics

STAR Therapeutics discovers and develops best-in-class antibody therapies for patients with unmet...

San Francisco, United States11–50Biotech, Healthcare
Series DTotal funding$215.0MSep 2025
29
Numerion Labs

Numerion Labs is an AI-native company accelerating drug discovery using cutting-edge machine lear...

San Francisco, United States11–50Artificial Intelligence, Biotech
Series DTotal funding$202.8MMar 2026
30
Loyal

Clinical-stage biotech developing the first FDA-approved drugs to extend the lifespan and healths...

San Francisco, United States11–50Animal Health, Biotech
Series CTotal funding$202.0MFeb 2026
31
Tenvie

Tenvie is led by innovators with biotech and precision-medicine expertise, pursuing better lives ...

San Francisco, United States11–50Biotech, Healthcare
Series ATotal funding$200.0MJan 2025
32
Cytovale

Medical diagnostics company focused on advancing early detection technologies to diagnose fast-mo...

San Francisco, United States51–200Diagnostics, Healthcare
Series DTotal funding$191.4MOct 2024
33
Ashvattha Therapeutics

Ashvattha Therapeutics is a clinical-stage biopharmaceutical company founded by Johns Hopkins sci...

San Francisco, United States11–50Biotech, Healthcare
Extension RoundTotal funding$188.0MJan 2025
34
SonoThera

Ultrasound-mediated non-viral gene therapy platform for non-invasive, targeted genetic medicine d...

South San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$185.8MJun 2026
35
Genome Medical

Telehealth genetic counseling and test-support for patients, providers, and life-sciences partner...

South San Francisco, United States51–200Digital Health, Genomics
Series DTotal funding$183.3MOct 2024
36
AusperBio

AusperBio is a Phase II clinical-stage biopharmaceutical company dedicated to transforming HBV tr...

San Francisco, United StatesBiotech, Healthcare
Series CTotal funding$183.0MAug 2026
37
Retro Biosciences

BioTech

San Francisco, United States51–200Biotech, Healthcare
Growth EquityTotal funding$180.0MMay 2026
38
Verge Genomics

Verge builds AI systems using proprietary patient brain data to help drug developers identify tar...

South San Francisco, United States11–50Biotech, Drug Discovery
Corporate RoundTotal funding$176.1MSep 2023
39
PACT Pharma

Biopharmaceutical company developing personalized neoantigen T cell receptor therapies for solid ...

South San Francisco, United States51–200Biotech, Healthcare
Series CTotal funding$170.0MMar 2024
40
Moonwalk Biosciences

Develops precision epigenetic medicines targeting adipose biology and cardiometabolic disease usi...

South San Francisco, United States11–50Biotech, Drug Discovery
Series BTotal funding$155.5MSep 2026
41
Clear Labs

Clear Labs provides food analytics while standardizing molecular food quality the global molecula...

San Francisco, United States51–200Biotech, Diagnostics
Series DTotal funding$150.2MDec 2024
42
Nura Bio

Clinical-stage biotech developing neuroprotective SARM1 inhibitor therapies for ALS and other neu...

South San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$143.8MJun 2026
43
E-Scape Bio

Preclinical-stage biopharmaceutical company developing small-molecule therapies targeting Alzheim...

South San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$136.0MSep 2020
44
Epic Bio

Epic Bio (now Epicrispr Biotechnologies) develops epigenetic gene therapies using ultracompact CR...

South San Francisco, United States11–50Biotech, Therapeutics
Series BTotal funding$123.0MMar 2025
45
Culture Biosciences

Culture Biosciences builds cloud-native software and bioreactor systems that help therapeutics an...

South San Francisco, United States11–50Agtech, Biotech
Series CTotal funding$122.0MDec 2025
46
Antiva Biosciences

Antiva Biosciences develops a first-in-class topical therapeutic for women with high-risk HPV inf...

South San Francisco, United States11–50Biotech, Healthcare
Series ETotal funding$121.0MApr 2023
47
Multiply Labs

Robotic production capacity for the pharma manufacturing industry

San Francisco, United States11–50Industrials, Robotics
Series BTotal funding$118.4MOct 2026
48
Siluria

Siluria Technologies pioneered commercial production of fuels and chemicals made from clean, abun...

San Francisco, United States51–200Biotech, Climate Tech
Extension RoundTotal funding$118.3MSep 2015
49
Unlearn

AI for medicine's future

San Francisco, United States51–200Artificial Intelligence, Healthcare
Series CTotal funding$116.8MFeb 2024
50
WildType

Develops cultivated sushi-grade salmon and seafood products using cell culture for restaurants an...

San Francisco, United States51–200Biotech, Food Tech
Series BTotal funding$116.0MFeb 2022