All Rankings

Top 100 Boston Startups 2026

The most-funded startups headquartered in Boston and Cambridge, Massachusetts, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $36.0B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&cities=Boston,Cambridge&states=Massachusetts&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API state filter leaves out companies with no recorded state; this list keeps them when the city matches.

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

51
Matchpoint Therapeutics

Matchpoint Therapeutics discovers precision small molecule medicines that use covalent bonding to...

Boston, United States11–50Biotech, Healthcare
Series BTotal funding$250.0MOct 2026
52
Seismic Therapeutic

Clinical-stage immunology biotech using machine learning to design biologic therapeutics for auto...

Cambridge, United States51–200Biotech, Drug Discovery
Extension RoundTotal funding$247.0MJul 2025
53
AIRNA

Clinical-stage biotech pioneering RNA editing therapeutics to repair disease-causing genetic vari...

Cambridge, United States11–50Biotech, Healthcare
Series BTotal funding$245.0MApr 2025
54
ArtBio

Clinical-stage radiopharmaceutical biotech developing alpha radioligand therapies for cancer, fou...

Cambridge, United States11–50Biotech, Healthcare
Series BTotal funding$245.0MJul 2025
55
Blitzy

Blitzy autonomously reverse engineers enterprise codebases, then generates, refactors, and modern...

Cambridge, United States11–50Artificial Intelligence, Developer Tools
Series BTotal funding$244.4MMay 2026
56
Openly

Openly provides customizable homeowners insurance through independent agents, combining modern te...

Boston, United States201–500Fintech, Insurtech
Growth EquityTotal funding$238.0MJan 2025
57
MOMA Therapeutics

MOMA Therapeutics develops precision medicines by targeting molecular machines that underlie dise...

Cambridge, United States51–200Biotech, Healthcare
Series BTotal funding$236.0MMay 2022
58
City Therapeutics

Biopharmaceutical company building next-generation RNAi therapeutics to improve treatment for pat...

Cambridge, United States51–200Biotech, Healthcare
Series BTotal funding$234.5MJun 2026
59
HomeTap

Provides home equity investments that give homeowners cash without monthly payments in exchange f...

Boston, United States201–500Financial Services, Fintech
Growth EquityTotal funding$222.0MDec 2025
60
Beacon Biosignals

Neurotechnology company combining FDA-cleared wearable EEG technology with AI to capture and anal...

Boston, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$213.0MApr 2026
61
Life Biosciences

Life Biosciences is a Boston-based biotechnology company pioneering epigenetic restoration to rev...

Boston, United States11–50Biotech, Healthcare
Series DTotal funding$212.0MApr 2026
62
Wasabi

Hot cloud object storage provider offering up to 80% cost savings versus hyperscalers like AWS S3.

Boston, United States201–500SaaS
Series DTotal funding$211.9MDec 2022
63
Hotspot Therapeutics

Allosteric drug discovery company targeting natural protein hotspots to develop cancer and autoim...

Boston, United States11–50Biotech, Healthcare
Series CTotal funding$210.0MNov 2021
64
Atalanta Therapeutics

Clinical-stage biotech developing branched siRNA therapeutics for neurological diseases using Nob...

Boston, United States51–200Biotech
Series BTotal funding$207.0MJan 2025
65
Ring Therapeutics

Ring Therapeutics is a Flagship Pioneering biotech developing Anellovector gene delivery therapie...

Cambridge, United States11–50Biotech
Series CTotal funding$203.5MMar 2023
66
Emulate

Emulate commercializes Organ-on-a-Chip microfluidic devices lined with living human cells, helpin...

Boston, United States51–200Biotech, Healthcare
Series ETotal funding$203.0MSep 2021
67
Rome Therapeutics

Rome Therapeutics is developing novel therapies for cancer and autoimmune diseases by illuminatin...

Boston, United States11–50Healthcare, Biotech
Series BTotal funding$199.0MJun 2023
68
Cognito Therapeutics

Neurotechnology for Alzheimer's disease

Cambridge, United States11–50Biotech, Healthcare
Series CTotal funding$198.0MMar 2026
69
Scipher Medicine

Precision immunology company using AI and clinico-genomic data to match autoimmune patients with ...

Boston, United States51–200Artificial Intelligence, Drug Discovery
Series DTotal funding$197.8MJul 2024
70
Satellite Bio

Develops off-the-shelf liver cell therapies that deliver functional hepatocytes to restore liver ...

Cambridge, United States11–50Biotech, Life Sciences
Series BTotal funding$196.5MJan 2024
71
Quaise Energy

MIT spinout developing gyrotron-powered millimeter-wave drilling technology to access superhot ge...

Cambridge, United States11–50Climate Tech
Series BTotal funding$195.0MJul 2026
72
Aera Therapeutics

Biotechnology company developing next-generation genetic medicines using a proprietary protein na...

Boston, United States51–200Biotech, Drug Discovery
Series ATotal funding$193.0MFeb 2023
73
Centrexion Therapeutics

Centrexion Therapeutics Corp. is focused on advancing the treatment of chronic moderate to severe...

Boston, United States11–50Biotech, Drug Discovery
Venture RoundTotal funding$192.4MJun 2023
74
Zoovu

Provides AI-powered product discovery and guided-selling tools that help enterprise retailers and...

Boston, United States201–500Artificial Intelligence, Data & Analytics
Growth EquityTotal funding$192.0MJun 2022
75
Notarize

Notarize lets users upload a document, verify their identity, and connect with a notary online in...

Boston, United States51–200Financial Services, Legal Tech
Series DTotal funding$187.4MMar 2021