All Rankings

Top 100 Boston Startups 2026

The most-funded startups headquartered in Boston and Cambridge, Massachusetts, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $36.0B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&cities=Boston,Cambridge&states=Massachusetts&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API state filter leaves out companies with no recorded state; this list keeps them when the city matches.

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

76
SimpliSafe

Wireless home security systems designed for easy self-installation and cellular monitoring.

Boston, United States1001–5000E-Commerce
Series ATotal funding$187.0MMay 2014
77
Cohere Health

Cohere Health builds clinically trained AI that automates prior authorization for health plans an...

Boston, United States501–1000Artificial Intelligence, Healthcare
Series CTotal funding$186.0MMay 2025
78
Creatio

Creatio is a no-code CRM and workflow automation platform with AI agents for sales, marketing, an...

Boston, United States1001–5000SaaS
Venture RoundTotal funding$185.0MJun 2024
79
Watershed Informatics

Cloud platform for omics data analysis and collaboration, serving biopharma and research teams to...

Cambridge, United States11–50Data & Analytics, Healthcare
Series CTotal funding$184.5MFeb 2024
80
iboss

iboss is an AI-powered SASE platform delivering Zero Trust network security and cloud-based secur...

Boston, United States201–500Cybersecurity, SaaS
Growth EquityTotal funding$180.0MDec 2020
81
Asimov

An integrated suite of cells, genes, and software to power advanced genetic design and biomanufac...

Boston, United States11–50Healthcare, Biotech
Series BTotal funding$179.7MJan 2023
82
HiFiBio

HiFiBiO Therapeutics advances transformative immunotherapies through a single-cell translational ...

Cambridge, United States51–200Biotech, Healthcare
Series DTotal funding$179.5MJun 2021
83
Teradar

Teradar develops terahertz sensing technology that delivers breakthrough sensing to save lives, u...

Boston, United States51–200Automotive, Defense Tech
Series BTotal funding$179.4MNov 2025
84
Code Metal

Boston AI startup providing verifiable, neuro-symbolic automated code translation for defense, au...

Boston, United StatesArtificial Intelligence, Developer Tools
Series BTotal funding$177.9MFeb 2026
85
Antares Therapeutics

Antares Therapeutics is a biotechnology company developing first-in-class precision medicines for...

Boston, United States11–50Biotech, Healthcare
Series ATotal funding$177.0MJun 2025
86
Binx Health

Boston-based binx health makes binx io, an FDA-cleared, CLIA-waived point-of-care molecular test ...

Boston, United States51–200Diagnostics, Healthcare
Series FTotal funding$169.0MApr 2024
87
Solo.io

Solo.io provides enterprise-grade cloud connectivity and agentic infrastructure, helping organiza...

Cambridge, United States51–200Artificial Intelligence, Developer Tools
Series CTotal funding$169.0MOct 2021
88
Posit

Enterprise data science platform trusted by 52 of the Fortune 100 for R, Python, and AI workflows.

Boston, United States201–500Artificial Intelligence, Developer Tools
Venture RoundTotal funding$168.6MJun 2022
89
Catalant

Marketplace connecting enterprises and private equity to independent consultants and curated team...

Boston, United States51–200HR Tech, SaaS
Series FTotal funding$168.2MMar 2021
90
Vedanta Bio

Vedanta Biosciences advances first-in-class live biotherapeutic products using defined consortia ...

Cambridge, United States51–200Biotech
Venture RoundTotal funding$166.5MApr 2023
91
7AI

7AI runs an agentic security platform whose AI agents investigate every security alert end to end...

Boston, United States11–50Artificial Intelligence, Cybersecurity
Series ATotal funding$166.0MDec 2025
92
Ori

Ori is a smart space company that designs multi-functional, robotic-powered interior solutions. R...

Boston, United States11–50Hardware, Robotics
Venture RoundTotal funding$166.0MFeb 2025
93
AcuityMD

Building first SaaS platform for medical device companies to get into the hands of more patients ...

Boston, United States11–50Healthcare
Venture RoundTotal funding$163.0MApr 2026
94
Casma Therapeutics

Casma Therapeutics is developing a technology that reprograms the autophagy pathway to degrade di...

Cambridge, United States11–50Biotech, Healthcare
Series CTotal funding$162.1MNov 2022
95
Lookout

Lookout develops a two-pronged defense combining Social Engineering Protection with mobile Endpoi...

Boston, United States501–1000Cybersecurity
Venture RoundTotal funding$161.0MAug 2014
96
RStudio

RStudio (now Posit PBC) is an open-source data science software company that builds the RStudio I...

Boston, United States201–500Developer Tools, SaaS
Venture RoundTotal funding$160.0MJun 2021
97
Alltrna

Biotech company developing universal tRNA medicines to restore disrupted protein production acros...

Cambridge, United States11–50Biotech
Series BTotal funding$159.0MAug 2023
98
Vizgen

Life sciences company developing spatial biology and multi-omics platforms to map gene and protei...

Cambridge, United States51–200Biotech, Life Sciences
Series CTotal funding$158.2MJun 2022
99
Crossbow Therapeutics

Biotech developing T-cell engager bispecific antibodies (T-Bolts) for cancer immunotherapy; Phase...

Cambridge, United States11–50Biotech
Series BTotal funding$157.0MMar 2026
100
HqO

HqO builds a real estate experience platform that helps commercial landlords unify portfolios, en...

Boston, United States51–200PropTech
Series DTotal funding$156.8MOct 2023