All Rankings

Top 100 Boston Startups 2026

The most-funded startups headquartered in Boston and Cambridge, Massachusetts, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $36.0B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&cities=Boston,Cambridge&states=Massachusetts&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API state filter leaves out companies with no recorded state; this list keeps them when the city matches.

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

26
Starburst

Starburst provides federated access to enterprise data, enabling AI workloads, faster insights, a...

Boston, United States201–500Analytics, Data & Analytics
Series DTotal funding$414.0MFeb 2022
27
Cloaked

Consumer privacy app providing email and phone aliases, data-broker removal, spam-call blocking, ...

Boston, United States51–200Cybersecurity, Identity
Series BTotal funding$404.0MMar 2026
28
BitSight

Cyber risk management platform providing security performance monitoring, exposure analysis, and ...

Boston, United States501–1000Compliance, Cybersecurity
Series ETotal funding$397.0MSep 2021
29
Inari Agriculture

AgTech company using AI-enabled predictive design and multiplex gene editing to create superior s...

Cambridge, United States201–500Biotech
Series G+Total funding$357.0MJan 2024
30
BE Biopharma

Biotech company pioneering Engineered B Cell Medicines (BCMs) to treat genetic diseases like Hemo...

Cambridge, United States51–200Biotech, Healthcare
Series CTotal funding$356.0MJan 2025
31
Dewpoint Therapeutics

Biotech company applying biomolecular condensate science to drug discovery across oncology, neuro...

Boston, United States51–200Life Sciences, Biotech
Series DTotal funding$346.1MSep 2025
32
Obsidian Therapeutics

Biotechnology company developing engineered tumor-infiltrating lymphocyte cell therapies to impro...

Cambridge, United States51–200Biotech
Series CTotal funding$325.0MApr 2024
33
Ledgebrook

Ledgebrook is an AI-native specialty insurance platform built by insurance insiders, offering who...

Boston, United States51–200Insurtech
Venture RoundTotal funding$306.0MOct 2026
34
Arbor Biotechnologies

Develops next-generation gene editing therapeutics for genetic diseases, advancing liver and CNS ...

Cambridge, United States51–200Biotech, Drug Discovery
Series CTotal funding$304.5MMar 2025
35
Concert AI

Provides AI and real-world oncology data solutions to life sciences companies, accelerating clini...

Boston, United States1001–5000Artificial Intelligence, Healthcare
Series CTotal funding$300.0MMar 2022
36
Valo Health

AI-enabled biotechnology company using large-scale human data and computation to accelerate drug ...

Boston, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$300.0MMar 2021
37
Walden Robotics

A full-stack physical AI company building and deploying general-purpose robots.

Cambridge, United States51–200Artificial Intelligence
SeedTotal funding$300.0MJul 2026
38
Arc Network

Arc provides developers, fintech startups, and enterprises with stablecoin-native infrastructure ...

Boston, United StatesCrypto & Web3
Venture RoundTotal funding$290.0MMay 2026
39
Flare Therapeutics

Biotech startup developing precision small molecule medicines targeting transcription factors for...

Cambridge, United States11–50Biotech, Healthcare
Series CTotal funding$290.0MJun 2026
40
Harbinger Health

Harbinger Health develops biology- and AI-powered blood tests that help clinicians resolve uncert...

Cambridge, United States51–200Artificial Intelligence, Healthcare
Series CTotal funding$290.0MApr 2026
41
Repertoire Immune Medicines

Repertoire Immune Medicines is a clinical-stage biotechnology company decoding the human T cell r...

Cambridge, United States51–200Biotech
Venture RoundTotal funding$289.0MApr 2025
42
Mediar Therapeutics

Mediar develops novel fibrosis treatments that disable myofibroblasts, aiming to slow or reverse ...

Cambridge, United States11–50Biotech, Healthcare
Series BTotal funding$282.0MJun 2026
43
Vendr.com

Vendr provides AI-powered SaaS procurement and pricing intelligence tools that help procurement t...

Boston, United States201–500SaaS, Supply Chain
Series BTotal funding$282.0MJun 2022
44
CereVasc

CereVasc develops the investigational eShunt System, a minimally invasive endovascular treatment ...

Boston, United States11–50Healthcare, Medical Devices
Series CTotal funding$278.9MJun 2026
45
Atavistik Bio

Develops selective allosteric therapeutics that modulate disease-causing proteins, aiming to tran...

Cambridge, United States11–50Biotech, Healthcare
Extension RoundTotal funding$265.3MMar 2026
46
Myeloid Therapeutics

Clinical-stage biotech pioneering in vivo multi-immune programming using proprietary mRNA-LNP CAR...

Cambridge, United States11–50Biotech, Therapeutics
Series BTotal funding$257.0MMay 2026
47
Celea Therapeutics

Celea advances deupirfenidone for people with serious respiratory diseases, targeting idiopathic ...

Boston, United States11–50Biotech, Healthcare
Series BTotal funding$255.0MJul 2026
48
PathAI

PathAI develops AI-powered precision pathology solutions that analyze tissue samples, helping pat...

Boston, United States201–500Artificial Intelligence, Biotech
Series CTotal funding$251.0MMay 2021
49
Immuta

Data provisioning company built on Govern, Provision, and Comply pillars, giving AI agents and hu...

Boston, United States201–500Cybersecurity, SaaS
Series ETotal funding$250.0MMay 2022
50
Liquid AI

AI model company building efficient neural networks (Liquid Neural Networks) for edge and cloud d...

Cambridge, United States51–200Artificial Intelligence, Developer Tools
Series BTotal funding$250.0MDec 2024