All Rankings

Top 100 Biotech Startups in Boston 2026

The most-funded biotechnology and genomics startups headquartered in Boston and Cambridge, Massachusetts, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $19.2B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Biotech,Genomics&countries=United+States&cities=Boston,Cambridge&states=Massachusetts&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API state filter leaves out companies with no recorded state; this list keeps them when the city matches.

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

26
City Therapeutics

Biopharmaceutical company building next-generation RNAi therapeutics to improve treatment for pat...

Cambridge, United States51–200Biotech, Healthcare
Series BTotal funding$234.5MJun 2026
27
Beacon Biosignals

Neurotechnology company combining FDA-cleared wearable EEG technology with AI to capture and anal...

Boston, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$213.0MApr 2026
28
Life Biosciences

Life Biosciences is a Boston-based biotechnology company pioneering epigenetic restoration to rev...

Boston, United States11–50Biotech, Healthcare
Series DTotal funding$212.0MApr 2026
29
Hotspot Therapeutics

Allosteric drug discovery company targeting natural protein hotspots to develop cancer and autoim...

Boston, United States11–50Biotech, Healthcare
Series CTotal funding$210.0MNov 2021
30
Atalanta Therapeutics

Clinical-stage biotech developing branched siRNA therapeutics for neurological diseases using Nob...

Boston, United States51–200Biotech
Series BTotal funding$207.0MJan 2025
31
Ring Therapeutics

Ring Therapeutics is a Flagship Pioneering biotech developing Anellovector gene delivery therapie...

Cambridge, United States11–50Biotech
Series CTotal funding$203.5MMar 2023
32
Emulate

Emulate commercializes Organ-on-a-Chip microfluidic devices lined with living human cells, helpin...

Boston, United States51–200Biotech, Healthcare
Series ETotal funding$203.0MSep 2021
33
Rome Therapeutics

Rome Therapeutics is developing novel therapies for cancer and autoimmune diseases by illuminatin...

Boston, United States11–50Healthcare, Biotech
Series BTotal funding$199.0MJun 2023
34
Cognito Therapeutics

Neurotechnology for Alzheimer's disease

Cambridge, United States11–50Biotech, Healthcare
Series CTotal funding$198.0MMar 2026
35
Scipher Medicine

Precision immunology company using AI and clinico-genomic data to match autoimmune patients with ...

Boston, United States51–200Artificial Intelligence, Drug Discovery
Series DTotal funding$197.8MJul 2024
36
Satellite Bio

Develops off-the-shelf liver cell therapies that deliver functional hepatocytes to restore liver ...

Cambridge, United States11–50Biotech, Life Sciences
Series BTotal funding$196.5MJan 2024
37
Aera Therapeutics

Biotechnology company developing next-generation genetic medicines using a proprietary protein na...

Boston, United States51–200Biotech, Drug Discovery
Series ATotal funding$193.0MFeb 2023
38
Centrexion Therapeutics

Centrexion Therapeutics Corp. is focused on advancing the treatment of chronic moderate to severe...

Boston, United States11–50Biotech, Drug Discovery
Venture RoundTotal funding$192.4MJun 2023
39
Asimov

An integrated suite of cells, genes, and software to power advanced genetic design and biomanufac...

Boston, United States11–50Healthcare, Biotech
Series BTotal funding$179.7MJan 2023
40
HiFiBio

HiFiBiO Therapeutics advances transformative immunotherapies through a single-cell translational ...

Cambridge, United States51–200Biotech, Healthcare
Series DTotal funding$179.5MJun 2021
41
Antares Therapeutics

Antares Therapeutics is a biotechnology company developing first-in-class precision medicines for...

Boston, United States11–50Biotech, Healthcare
Series ATotal funding$177.0MJun 2025
42
Vedanta Bio

Vedanta Biosciences advances first-in-class live biotherapeutic products using defined consortia ...

Cambridge, United States51–200Biotech
Venture RoundTotal funding$166.5MApr 2023
43
Casma Therapeutics

Casma Therapeutics is developing a technology that reprograms the autophagy pathway to degrade di...

Cambridge, United States11–50Biotech, Healthcare
Series CTotal funding$162.1MNov 2022
44
Alltrna

Biotech company developing universal tRNA medicines to restore disrupted protein production acros...

Cambridge, United States11–50Biotech
Series BTotal funding$159.0MAug 2023
45
Vizgen

Life sciences company developing spatial biology and multi-omics platforms to map gene and protei...

Cambridge, United States51–200Biotech, Life Sciences
Series CTotal funding$158.2MJun 2022
46
Crossbow Therapeutics

Biotech developing T-cell engager bispecific antibodies (T-Bolts) for cancer immunotherapy; Phase...

Cambridge, United States11–50Biotech
Series BTotal funding$157.0MMar 2026
47
Strand Therapeutics

Strand develops complex mRNA medicines for cancer and autoimmune disease, taking them from design...

Boston, United States51–200Biotech, Healthcare
Series BTotal funding$153.0MAug 2025
48
Cullinan Oncology

Cullinan Therapeutics develops clinical-stage therapies that modulate the immune system to treat ...

Cambridge, United States51–200Biotech, Healthcare
Series ATotal funding$150.0MOct 2017
49
Kinaset Therapeutics

Novel therapeutics for severe respiratory diseases

Boston, United States11–50Biotech, Healthcare
Series BTotal funding$143.0MJan 2026
50
Invaio Sciences

Invaio Sciences is a biotech company developing agricultural biotechnologies for sustainable farm...

Cambridge, United States51–200Biotech, Climate Tech
Series CTotal funding$142.0MMay 2021