All Rankings

Top Series B Companies in the US 2026

Private companies headquartered in the United States whose latest recorded round was Series B, ranked by disclosed lifetime funding.

Known total funding for 100 of 100 ranked companies: $59.4B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no funding stage filter, so this includes every stage, not only Series B.

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

26
Ollin Biosciences

Clinical-stage biopharmaceutical company dedicated to developing best-in-disease therapies for vi...

Austin, United States11–50Biotech, Healthcare
Series BTotal funding$430.0MJun 2026
27
JetZero

JetZero is developing the Z4, a blended wing body commercial aircraft designed for zero-emission ...

Long Beach, United States51–200Climate Tech, Defense Tech
Series BTotal funding$410.0MJan 2026
28
80 Acres Farms

80 Acres is a vertical farming company that produces a mix of produce through highly automated, h...

Hamilton, United States501–1000Climate Tech, Agtech
Series BTotal funding$408.4MOct 2025
29
Soufflé Therapeutics

Biotechnology company developing cell-specific siRNA-based genetic medicines targeting skeletal m...

Watertown, United States51–200Biotech, Healthcare
Series BTotal funding$406.6MOct 2026
30
Cloaked

Consumer privacy app providing email and phone aliases, data-broker removal, spam-call blocking, ...

Boston, United States51–200Cybersecurity, Identity
Series BTotal funding$404.0MMar 2026
31
Meshy

AI-powered tool that generates 3D models from text and images, supporting multiple art styles wit...

Sunnyvale, United States51–200Artificial Intelligence
Series BTotal funding$400.0MJul 2026
32
Mariana Minerals

Mariana Minerals develops and operates software-first critical-minerals projects, supplying mater...

Houston, United States51–200Artificial Intelligence, Defense Tech
Series BTotal funding$395.0MAug 2026
33
Gimlet Labs

Gimlet Labs is an applied research lab that builds high-performance AI systems, including serverl...

San Francisco, United States11–50Artificial Intelligence, Developer Tools
Series BTotal funding$392.0MSep 2026
34
Little Leaf

Little Leaf Farms grows sustainably produced baby lettuces year-round in technologically advanced...

Devens, United States201–500Climate Tech
Series BTotal funding$390.0MJun 2022
35
XCENA

Memory-centric computing for AI infrastructure.

San Jose, United States11–50Artificial Intelligence, Semiconductors
Series BTotal funding$377.0MJun 2026
36
AMCA

Advanced Manufacturing Company of America designs and manufactures advanced aerospace and defense...

El Segundo, United States11–50Defense Tech
Series BTotal funding$376.5MMay 2026
37
Cyara

Cyara is the global leader in AI-powered customer experience assurance, providing a unified platf...

Redwood City, United States201–500CRM, SaaS
Series BTotal funding$375.0MJan 2022
38
Human Longevity

Human Longevity combines genomic science with clinical care to detect disease before symptoms and...

San Diego, United States51–200Biotech
Series BTotal funding$369.8MAug 2024
39
Cowboy Space

Cowboy Space builds solar-powered orbital data centers, combining rockets and satellites to deliv...

San Francisco, United States11–50Aerospace, Space Tech
Series BTotal funding$365.0MMay 2026
40
Tilly

Tilly pairs autism-care and special education professionals with children while providing softwar...

Miami, United States51–200Healthcare, SaaS
Series BTotal funding$364.0MOct 2021
41
Chronograph

Chronograph helps private capital investors structure, access, report, and analyze proprietary in...

New York, United States51–200Fintech, SaaS
Series BTotal funding$353.0MJun 2026
42
Bedrock Robotics

Bedrock Robotics builds autonomous systems that retrofit existing heavy construction equipment wi...

San Francisco, United States51–200Construction Tech, Robotics
Series BTotal funding$350.0MFeb 2026
43
Thriveworks

Nationwide mental-health provider offering in-person and online therapy, psychiatry, and medicati...

Lynchburg, United States1001–5000Digital Health, Healthcare
Series BTotal funding$340.2MJul 2021
44
Gupshup

Deploy secure, scalable AI Agents with enterprise-ready infrastructure. Gupshup powers billions o...

San Francisco, United States501–1000Artificial Intelligence, SaaS
Series BTotal funding$340.0MNov 2021
45
Mysten Labs

Mysten Labs develops tools that make web3 secure, reliable, and ready for mass adoption. They cre...

Palo Alto, United States51–200Crypto & Web3, Developer Tools
Series BTotal funding$336.0MSep 2022
46
Crystalys Therapeutics

Clinical-stage biopharmaceutical company focused on advancing innovative therapies to address the...

San Diego, United States11–50Biotech, Healthcare
Series BTotal funding$335.0MJul 2026
47
ProFound Therapeutics

Biotech company pioneering discovery of an expanded human proteome to develop new medicines for c...

United States11–50Biotech
Series BTotal funding$333.0MMay 2026
48
Odyssey.ml

Odyssey develops interactive world models that understand and simulate physical environments for ...

Palo Alto, United States11–50Artificial Intelligence
Series BTotal funding$328.0MJun 2026
49
REGENT

REGENT develops all-electric Seaglider vessels that fly over water, giving ferry, airline, and lo...

North Kingstown, United States11–50Aerospace, Climate Tech
Series BTotal funding$327.1MAug 2026
50
Medici Brands

Consumer brand holding company that creates and grows iconic brands across food, technology, and ...

New York, United States51–200
Series BTotal funding$325.0MSep 2026