All Rankings

Top Series B Companies in the US 2026

Private companies headquartered in the United States whose latest recorded round was Series B, ranked by disclosed lifetime funding.

Known total funding for 100 of 100 ranked companies: $59.4B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no funding stage filter, so this includes every stage, not only Series B.

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

51
Wispr Flow

Wispr Flow is the voice-to-text AI that turns speech into clear, polished writing in every app.

San Francisco, United States11–50Artificial Intelligence, Natural Language Processing
Series BTotal funding$323.6MMay 2026
52
Solve Therapeutics

Solve Therapeutics is a biopharmaceutical company that develops next-gen antibody-drug conjugates...

Belmont, United States11–50Life Sciences, Biotech
Series BTotal funding$321.0MNov 2025
53
ReCharge

Leading subscription management platform powering recurring revenue for over 20,000 ecommerce bra...

Santa Monica, United States501–1000E-Commerce, SaaS
Series BTotal funding$312.0MSep 2021
54
DataDirect Networks

DDN is the world's leading AI and data intelligence company, empowering organizations with high-p...

Chatsworth, United States1001–5000Artificial Intelligence, Cloud
Series BTotal funding$309.9MJan 2025
55
Twelve Labs

Video intelligence platform that builds multimodal AI foundation models enabling precise semantic...

San Francisco, United States51–200Artificial Intelligence, Machine Learning
Series BTotal funding$307.1MJul 2026
56
Biz2Credit

Biz2Credit provides an online financing platform that matches small businesses with funding optio...

New York, United States201–500Fintech, Financial Services
Series BTotal funding$302.0MJan 2016
57
LTK (ShopLTK)

Creator-driven shopping platform connecting creators, brands, and shoppers to monetize content an...

Dallas, United States501–1000Creator Economy, E-Commerce
Series BTotal funding$300.0MNov 2021
58
Simile

AI simulation platform that builds high-fidelity digital twins of real people to predict human be...

Palo Alto, United States1–10Artificial Intelligence, Generative AI
Series BTotal funding$300.0MJul 2026
59
Valo Health

AI-enabled biotechnology company using large-scale human data and computation to accelerate drug ...

Boston, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$300.0MMar 2021
60
Sesame AI

Interdisciplinary product and research team building voice companions for daily life, aiming for ...

San Francisco, United States51–200Artificial Intelligence
Series BTotal funding$297.5MOct 2025
61
Immunai

Immunai maps the immune system using single-cell genomics and ML to accelerate drug discovery and...

New York, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$295.0MOct 2021
62
Tenex AI

AI-native Managed Detection and Response service that triages alerts, investigates threats, and a...

Sarasota, United States51–200Infrastructure, Artificial Intelligence
Series BTotal funding$295.0MMar 2026
63
CertiK

CertiK is a pioneer in blockchain security, utilizing best-in-class AI technology to secure and m...

New York, United States201–500Artificial Intelligence, Crypto & Web3
Series BTotal funding$292.5MApr 2022
64
Enfabrica

AI networking silicon and software company building high-performance SuperNIC chips and solutions...

Mountain View, United States51–200Artificial Intelligence, Infrastructure
Series BTotal funding$290.0MDec 2024
65
Panthalas

Develops ocean-deployed renewable energy platforms with embedded compute to supply low-cost, zero...

Portland, United States51–200Clean Energy, Cloud
Series BTotal funding$289.1MMay 2026
66
Mozido

American mobile payments and financial services platform providing cloud-based payment and loyalt...

San Francisco, United States201–500E-Commerce, Fintech
Series BTotal funding$288.5MOct 2014
67
AltruBio

AltruBio develops safer, more durable therapeutics for immunological diseases, targeting unmet ne...

San Francisco, United States11–50Biotech, Healthcare
Series BTotal funding$288.0MMay 2024
68
Latigo Biotherapeutics

Clinical-stage company developing non-opioid pain medicines

Thousand Oaks, United States51–200Biotech, Healthcare
Series BTotal funding$285.0MMar 2025
69
Up&Up

Up&Up is a rent-to-own platform that lets renters build equity toward homeownership or savings wh...

New York, United States11–50Financial Services, Real Estate
Series BTotal funding$284.3MNov 2021
70
Breeze Airways

Breeze Airways operates an airline that flies people to destinations and offers flight bookings t...

Salt Lake City, United States1001–5000Aerospace, CRM
Series BTotal funding$283.0MAug 2021
71
Mediar Therapeutics

Mediar develops novel fibrosis treatments that disable myofibroblasts, aiming to slow or reverse ...

Cambridge, United States11–50Biotech, Healthcare
Series BTotal funding$282.0MJun 2026
72
Vendr.com

Vendr provides AI-powered SaaS procurement and pricing intelligence tools that help procurement t...

Boston, United States201–500SaaS, Supply Chain
Series BTotal funding$282.0MJun 2022
73
Expedition Therapeutics

Clinical-stage biotech advancing a Phase 2 COPD therapy.

San Francisco, United States1–10Biotech, Healthcare
Series BTotal funding$280.0MAug 2026
74
Trackonomy

Trackonomy provides smart hardware and software labels that give logistics, healthcare, and indus...

San Jose, United States201–500SaaS, Supply Chain
Series BTotal funding$275.0MJan 2023
75
Ontra Mobility

Ontra provides transit agencies with connected software for network planning, service operations,...

New York, United States1–10Artificial Intelligence, Climate Tech
Series BTotal funding$270.0MOct 2021