Lightstone Ventures
Lightstone Ventures is a biotech and medtech venture capital firm founded in 2012, headquartered in Portola Valley, California, with additional offices in Boston and Dublin. The firm invests in first-in-class biotech therapies across CNS, immunology, oncology, and ophthalmology, as well as medtech companies advancing personalized medicine and targeted therapeutics. Its track record includes 20 IPOs and 22 acquisitions among portfolio companies.
Menlo Park, United States · 37+ investments · 63 portfolio companies
- Headquarters
- Menlo Park, United States
- Founded
- 2012
- Website
- lightstonevc.com
- AUM
- $375.0M
- Portfolio Companies
- 63
- Total Investments
- 37
- Last Investment
- Sep 2025
- Geographic Focus
- United States, Ireland, Singapore
Indexed holds 63 portfolio companies and 37 funding rounds for this investor. The full record is or through the API.
Investment Thesis
Lightstone Ventures is a Venture Capital firm based in Menlo Park, United States. It has made 37 investments, including Cabochon Aesthetics, Trishula Therapeutics and Ardian. Focus areas include Biotech and Medical Devices.
Portfolio63
Showing 48 of 63 recorded portfolio companies.
Co-investors24
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24 co-investors across 100 shared portfolio companies — who they back alongside, and how often they lead.
Venture Capital ×19 · Corporate VC ×3 · Private Equity ×1 · 38 shared rounds
Investment History
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