All Rankings

Top 100 Seattle Startups 2026

The most-funded startups headquartered in Seattle, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $13.1B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&cities=Seattle&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

1
Stoke Space

Stoke Space develops Nova, a fully reusable rocket designed to provide affordable, responsive tra...

Seattle, United States51–200Space Tech, Industrials
Series ETotal funding$2.4BSep 2026
2
EigenLayer

EigenLayer enables Ethereum restaking, allowing stakers to secure Actively Validated Services (AV...

Seattle, United States51–200Crypto & Web3
Venture RoundTotal funding$450.0MApr 2025
3
Truveta

Truveta provides de-identified, real-world healthcare data and analytics that help life sciences ...

Seattle, United States201–500Artificial Intelligence, Data & Analytics
Series CTotal funding$415.0MJan 2025
4
Sonoma Biotherapeutics

Develops engineered regulatory T cell therapies to restore immune balance and treat autoimmune an...

Seattle, United States51–200Biotech, Life Sciences
Corporate RoundTotal funding$410.0MSep 2024
5
Umoja

Develops in vivo CAR T cell therapies that generate CAR T cells inside patients to treat cancer.

Seattle, United States201–500Biotech, Drug Discovery
Series CTotal funding$363.0MJan 2025
6
Qumulo

Enterprise-grade unstructured data platform for managing file and object data across on-premises,...

Seattle, United States201–500Cloud, Infrastructure
Series ETotal funding$347.3MJul 2020
7
Zenoti

Zenoti is an all-in-one cloud software for spas, salons, med spas and fitness centers SaaS Health...

Seattle, United States501–1000Beauty, Healthcare
Extension RoundTotal funding$311.0MJun 2021
8
Rec Room

Rec Room is a free cross-platform social gaming service where players build, share, and play user...

Seattle, United States51–200AR/VR, Gaming
Series FTotal funding$300.4MDec 2021
9
Chapter

Chapter is a technology-enabled Medicare advisory that compares plans and connects older American...

Seattle, United States201–500Digital Health, Fintech
Series ETotal funding$275.0MApr 2026
10
XBOW

XBOW is an AI-powered offensive security company that automates pentesting and accelerates the di...

Seattle, United States51–200Artificial Intelligence, Cybersecurity
Extension RoundTotal funding$270.0MMay 2026
11
98point6

Virtual care technology platform licensing AI-powered tools to health systems for async and real-...

Seattle, United States201–500Digital Health, Healthcare
ConvertibleTotal funding$266.1MSep 2022
12
Flexe

Flexe provides flexible warehousing infrastructure that helps retailers and brands run e-commerce...

Seattle, United States51–200Logistics
Series DTotal funding$256.3MJul 2022
13
Commerce Fabric

Fabric helps brands and retailers manage products through an autonomous agent that handles data e...

Seattle, United States51–200E-Commerce, Retail
Series CTotal funding$249.5MFeb 2022
14
Viome

Viome is an at-home health testing company that uses AI-powered RNA sequencing to analyze the gut...

Seattle, United States51–200Healthcare
Series DTotal funding$218.5MJan 2024
15
FlyHomes

Real estate technology company that provides homebuyers with financial products and services to m...

Seattle, United States201–500Fintech, PropTech
Series DTotal funding$205.0MJul 2025
16
Karat

Karat is a workforce transformation partner that combines live interviews from trained Interview ...

Seattle, United States201–500Artificial Intelligence, SaaS
Series CTotal funding$199.7MOct 2021
17
Callio Therapeutics

Callio Therapeutics is a clinical-stage biotech developing dual-payload antibody-drug conjugates,...

Seattle, United States1–10Biotech, Oncology
Series ATotal funding$187.0MMar 2025
18
DexCare

Digital health platform providing an operating system for care delivery, helping health systems m...

Seattle, United States51–200Digital Health, Healthcare
Series CTotal funding$185.2MJun 2023
19
Stackline

Stackline provides consumer brands with ecommerce intelligence and automation software for analyz...

Seattle, United States201–500Analytics, E-Commerce
Venture RoundTotal funding$180.0MJun 2021
20
Outpace Bio

Seattle biotech using AI-powered protein design to engineer next-generation cell therapies, impro...

Seattle, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$174.0MAug 2024
21
Variant Bio

Variant Bio develops life-saving therapies by studying the genetics of people with exceptional he...

Seattle, United States11–50Life Sciences
Corporate RoundTotal funding$171.0MJan 2025
22
InduPro

Discovering and redefining cell-surface interactions to modulate biological disease pathways

Seattle, United States11–50Biotech
Series BTotal funding$162.0MAug 2026
23
Seeq

Seeq provides advanced industrial analytics and AI software that helps process manufacturers unlo...

Seattle, United States201–500Artificial Intelligence, Data & Analytics
Series DTotal funding$153.0MAug 2024
24
Shape Therapeutics

A development stage biotechnology company based in Seattle WA and San Diego CA that is establishi...

Seattle, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$147.5M
25
Overland AI

Builds autonomous off‑road ground vehicles and an autonomy stack for defense customers, providing...

Seattle, United States51–200Artificial Intelligence, Autonomous Vehicles
Series BTotal funding$143.5MFeb 2026