All Rankings

Top 100 AI Startups in San Francisco 2026

The most-funded artificial intelligence and machine learning startups headquartered in San Francisco, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $461.1B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Artificial+Intelligence,Generative+AI,Machine+Learning&countries=United+States&cities=San+Francisco&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

76
Twelve Labs

Video intelligence platform that builds multimodal AI foundation models enabling precise semantic...

San Francisco, United States51–200Artificial Intelligence, Machine Learning
Series BTotal funding$307.1MJul 2026
77
TRM Labs

TRM Labs provides blockchain intelligence software and AI agents that help financial institutions...

San Francisco, United States201–500Artificial Intelligence, Compliance
Series CTotal funding$303.9MFeb 2026
78
Periodic Labs

Periodic Labs develops artificial intelligence systems that simulate and predict the properties o...

San Francisco, United States51–200Infrastructure, Artificial Intelligence
SeedTotal funding$300.0MSep 2025
79
Sesame AI

Interdisciplinary product and research team building voice companions for daily life, aiming for ...

San Francisco, United States51–200Artificial Intelligence
Series BTotal funding$297.5MOct 2025
80
Instabase

Instabase helps enterprises transform complex documents into verifiable, auditable data, using AI...

San Francisco, United States201–500Artificial Intelligence, Infrastructure
Series DTotal funding$295.0MJan 2025
81
Tome

Developer of a storytelling tool designed to reduce the time required for creating slides.

San Francisco, United States11–50Artificial Intelligence
Series CTotal funding$294.6MAug 2025
82
Deepgram

Deepgram provides speech-to-text, text-to-speech, and voice-agent APIs that help developers build...

San Francisco, United States51–200Artificial Intelligence, Audio
Series CTotal funding$286.0MJan 2026
83
Iru

AI-powered IT and security platform (formerly Kandji) that unifies identity and access management...

San Francisco, United States201–500Artificial Intelligence, Cybersecurity
Series DTotal funding$284.4MJul 2024
84
Verana Health

Verana Health is a digital health company that delivers quality drug lifecycle and medical practi...

San Francisco, United States51–200Artificial Intelligence, Healthcare
Series ETotal funding$280.0MJan 2022
85
Sygaldry

YC-backed startup building quantum-accelerated AI servers combining multiple qubit types to speed...

San Francisco, United States1–10Artificial Intelligence, Hardware
Series ATotal funding$278.0MApr 2026
86
Nimble Robotics

Nimble operates autonomous fulfillment centers using AI-powered warehouse robots to pick, pack, s...

San Francisco, United States201–500Artificial Intelligence, Logistics
Series BTotal funding$269.0MFeb 2026
87
Redpanda

Provides a high-performance, Kafka-compatible streaming platform and Agentic Data Plane to connec...

San Francisco, United States51–200Artificial Intelligence, Databases
Series DTotal funding$265.5MApr 2025
88
Typeface

Typeface is a generative AI platform for enterprises that enables personalized, on-brand content ...

San Francisco, United States201–500Artificial Intelligence, Creator Economy
Series CTotal funding$265.0MOct 2025
89
Nirvana

Nirvana harnesses data and AI to revolutionize commercial trucking insurance, helping fleets lowe...

San Francisco, United States51–200Artificial Intelligence, Fintech
Series DTotal funding$262.2MDec 2025
90
Fundamental

AI lab building NEXUS, a Large Tabular Model purpose-built for structured enterprise data, enabli...

San Francisco, United States11–50Artificial Intelligence, Data & Analytics
Series ATotal funding$255.0MFeb 2026
91
viz.ai

Viz.ai provides an AI-powered care coordination platform that analyzes medical imaging, delivers ...

San Francisco, United States201–500Artificial Intelligence, Healthcare
Series DTotal funding$251.8MApr 2022
92
Apollo.io

Apollo provides a data intelligence and sales engagement platform that helps sales teams find, en...

San Francisco, United States11–50Artificial Intelligence, CRM
Series DTotal funding$251.2MAug 2023
93
Niantic Spatial

AI spatial computing platform

San Francisco, United States51–200Artificial Intelligence, Defense Tech
Corporate RoundTotal funding$250.0MMar 2025
94
Assort Health

Agentic AI platform for healthcare call centers that automates patient phone calls, reduces hold ...

San Francisco, United States51–200Artificial Intelligence, Conversational AI
Venture RoundTotal funding$244.0MJun 2026
95
Starship

Builds autonomous delivery robots that deliver groceries, food and supplies to campuses, retailer...

San Francisco, United States201–500Logistics, Robotics
Series CTotal funding$239.2MOct 2025
96
Cyberhaven

Cyberhaven provides an AI-native data-security platform combining data lineage, DSPM, DLP, inside...

San Francisco, United States201–500Artificial Intelligence, Cybersecurity
Series DTotal funding$236.5MApr 2025
97
Standard AI

Standard AI provides computer-vision software that helps physical retailers analyze shopper behav...

San Francisco, United States51–200Artificial Intelligence, Retail
Series CTotal funding$235.5MFeb 2021
98
Omni Analytics

Omni Analytics is a business intelligence platform helping organizations analyze data with modern...

San Francisco, United States51–200Developer Tools, SaaS
Series ATotal funding$230.5MJul 2026
99
Emergent

Autonomous coding agents for software migration and modernization

San Francisco, United States11–50Developer Tools, Generative AI
Series CTotal funding$223.0MJul 2026
100
Sardine

Sardine provides risk-free, instant settlement for ACH and cards. Their comprehensive KYC, fraud,...

San Francisco, United States51–200Artificial Intelligence, Fintech
Extension RoundTotal funding$221.6MMay 2026