All Rankings

Top 100 AI Startups in San Francisco 2026

The most-funded artificial intelligence and machine learning startups headquartered in San Francisco, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $461.1B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Artificial+Intelligence,Generative+AI,Machine+Learning&countries=United+States&cities=San+Francisco&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

51
Unconventional AI

Unconventional AI develops physical computing systems that use dynamical hardware and co-designed...

San Francisco, United States11–50Artificial Intelligence, Semiconductors
SeedTotal funding$475.0MDec 2025
52
Peregrine

Peregrine creates software that helps organizations integrate and analyze large and complex data ...

San Francisco, United States201–500Artificial Intelligence, Cybersecurity
Series DTotal funding$470.0MJun 2026
53
Armada

Full-stack edge computing platform providing connectivity, compute, and AI solutions for remote a...

San Francisco, United States201–500Artificial Intelligence, Infrastructure
Series BTotal funding$469.0MMay 2026
54
Magic

Magic is training frontier models to build an AI software engineer that feels like a co-worker.

San Francisco, United States51–200Artificial Intelligence, Developer Tools
Series CTotal funding$465.0MAug 2024
55
Decart

Decart is a frontier AI lab that builds real-time generative video models and the infrastructure ...

San Francisco, United States51–200Developer Tools, Generative AI
Series BTotal funding$453.0MMay 2026
56
Armadin

AI-native cybersecurity company founded by ex-Mandiant CEO Kevin Mandia, building an autonomous o...

San Francisco, United States11–50Artificial Intelligence, Cybersecurity
Series BTotal funding$445.5MOct 2026
57
Owkin

Owkin builds agentic AI scientists trained on multimodal patient data to help biopharma teams acc...

San Francisco, United States201–500Artificial Intelligence, Biotech
Corporate RoundTotal funding$445.2MJan 2023
58
Bright Machines

Bright Machines integrates advanced software and robotics in Bright Factory assembly operations t...

San Francisco, United States201–500Artificial Intelligence
Series CTotal funding$437.0MJun 2024
59
6Sense

6sense provides AI-powered revenue intelligence that helps B2B sales and marketing teams identify...

San Francisco, United States1001–5000Artificial Intelligence, Marketing Tech
Series ETotal funding$426.0MJan 2022
60
Transcarent

Transcarent is the One Place for Health and Care that makes it easy for people to access high-qua...

San Francisco, United States501–1000Life Sciences, Artificial Intelligence
Venture RoundTotal funding$424.0MJan 2025
61
Factory

Factory delivers an agent-native autonomy stack for enterprise engineering teams, using AI agents...

San Francisco, United States11–50Artificial Intelligence, Developer Tools
Venture RoundTotal funding$420.0MSep 2026
62
Tempo

Tempo offers guided strength classes for all levels, with real-time coach feedback, custom guidan...

San Francisco, United States51–200Digital Health, Healthcare
Extension RoundTotal funding$397.5MApr 2021
63
Gimlet Labs

Gimlet Labs is an applied research lab that builds high-performance AI systems, including serverl...

San Francisco, United States11–50Artificial Intelligence, Developer Tools
Series BTotal funding$392.0MSep 2026
64
EvenUp

AI-powered legal technology platform for personal injury law firms, automating demand letter gene...

San Francisco, United States501–1000Artificial Intelligence, Legal Tech
Series ETotal funding$385.0MOct 2025
65
Exa

Exa provides web search and crawling APIs that give AI developers real-time information for agent...

San Francisco, United States1–10Artificial Intelligence
Series CTotal funding$379.0MMay 2026
66
Monte Carlo

Data observability platform that monitors data quality across the data stack using ML to detect f...

San Francisco, United States201–500Artificial Intelligence, Infrastructure
Series ETotal funding$371.0MOct 2025
67
Clarify Health Solutions

Healthcare analytics platform providing AI-powered insights to help providers and payers optimize...

San Francisco, United States51–200Artificial Intelligence, Healthcare
Series DTotal funding$366.5MApr 2022
68
Ambience Healthcare

AI-native platform for clinical documentation, coding, and workflows that uses ambient listening ...

San Francisco, United States51–200Artificial Intelligence, Healthcare
Series CTotal funding$343.0MJul 2025
69
Gupshup

Deploy secure, scalable AI Agents with enterprise-ready infrastructure. Gupshup powers billions o...

San Francisco, United States501–1000Artificial Intelligence, SaaS
Series BTotal funding$340.0MNov 2021
70
Ironclad

Ironclad provides contract lifecycle management and clickwrap software that helps legal and busin...

San Francisco, United States201–500Artificial Intelligence, Legal Tech
Series ETotal funding$334.0MJan 2022
71
Zip

Zip provides an AI platform for enterprise procurement, helping businesses streamline purchasing ...

San Francisco, United States201–500Artificial Intelligence, SaaS
Series DTotal funding$333.0MOct 2024
72
Writer

Writer is an enterprise AI platform that lets organizations deploy agents and workflows using the...

San Francisco, United States201–500Artificial Intelligence, SaaS
Series CTotal funding$326.0MNov 2024
73
Wispr Flow

Wispr Flow is the voice-to-text AI that turns speech into clear, polished writing in every app.

San Francisco, United States11–50Artificial Intelligence, Natural Language Processing
Series BTotal funding$323.6MMay 2026
74
Hightouch

Hightouch provides an Agentic Composable CDP that lets marketers activate governed warehouse data...

San Francisco, United States51–200Analytics, Artificial Intelligence
Series DTotal funding$322.7MApr 2026
75
SparkCognition

Empowering the world’s problem-solvers and catalyzing growth with their proven artificial intelli...

San Francisco, United States201–500Energy, Artificial Intelligence
Series DTotal funding$320.0MJan 2022