All Rankings

Top 100 AI Startups in Boston 2026

The most-funded artificial intelligence and machine learning startups headquartered in Boston and Cambridge, Massachusetts, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $14.3B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?industries=Artificial+Intelligence,Generative+AI,Machine+Learning&countries=United+States&cities=Boston,Cambridge&states=Massachusetts&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API state filter leaves out companies with no recorded state; this list keeps them when the city matches.

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

51
Linus Health

Digital brain health platform for early detection and care of cognitive disorders using AI and ne...

Boston, United States51–200Artificial Intelligence, Healthcare
Series BTotal funding$64.9MJul 2021
52
DeepCure

AI-powered small molecule drug discovery company targeting immune and inflammatory diseases using...

Boston, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$64.6MApr 2024
53
Axoft

Axoft develops soft implantable electronics and a Brain Foundation Model to improve neural signal...

Cambridge, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$63.0MApr 2026
54
AI Proteins

AI Proteins pioneers programmable miniproteins—engineered from scratch with AI, robotics, and syn...

Boston, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$59.7MNov 2025
55
Cellular Intelligence

Cellular Intelligence (formerly Somite AI) is a Boston-based AI-native biotech building the first...

Boston, United States11–50Healthcare, Digital Health
Series ATotal funding$57.1MMay 2025
56
Gradient AI

AI-powered intelligence platform for insurance industry risk prediction and analysis.

Boston, United States51–200Artificial Intelligence, SaaS
Series CTotal funding$56.1MJul 2024
57
ISEE

ISEE builds AI-powered autonomous yard trucks using MIT-derived technology, designed to operate s...

Cambridge, United States51–200Artificial Intelligence
Series BTotal funding$55.0MNov 2022
58
Oncorps

AI platform providing 100% transaction oversight, NAV reporting, and regulatory compliance monito...

Boston, United States51–200Artificial Intelligence, Fintech
Growth EquityTotal funding$55.0MDec 2025
59
TileDB

TileDB builds the world's most powerful database technology to accelerate breakthroughs from data...

Cambridge, United States51–200Artificial Intelligence, Developer Tools
Series BTotal funding$54.0MOct 2023
60
Somite AI

AI company building foundation models for human stem cells to accelerate cell therapy development...

Boston, United States1–10Artificial Intelligence, Biotech
Series ATotal funding$52.3MJun 2025
61
Abiologics

AI-powered biotech creating Synteins, a new class of supranatural biologics surpassing limitation...

Cambridge, United States1–10Artificial Intelligence, Biotech
Series ATotal funding$50.0MJul 2024
62
Expedition Medicines

AI-powered drug discovery platform using generative design to create small molecule medicines for...

Cambridge, United States11–50Artificial Intelligence, Biotech
Corporate RoundTotal funding$50.0MOct 2025
63
Mirai Bio

Machine intelligence-based open platform for end-to-end genetic medicine development, enabling de...

Cambridge, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$50.0MSep 2024
64
Montai Therapeutics

AI-driven drug discovery company harnessing nature's chemical intelligence to develop breakthroug...

Cambridge, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$50.0MDec 2022
65
Clairity

AI-powered platform that predicts a woman's five-year breast cancer risk from standard mammograms...

Boston, United States11–50Artificial Intelligence, Healthcare
Series BTotal funding$49.7MNov 2025
66
Catena Labs

AI-native financial infrastructure company founded by Circle co-founder Sean Neville, building op...

Boston, United States11–50Artificial Intelligence, Crypto & Web3
Series ATotal funding$48.0MMay 2026
67
Helix Nanotechnologies

Next-generation mRNA platform to solve cancer, COVID and climate.

Boston, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$45.0MMar 2022
68
Consensus

Consensus is an AI workspace that helps researchers, students, and clinicians search, synthesize,...

Boston, United States11–50Artificial Intelligence, SaaS
Series BTotal funding$44.5MMay 2026
69
Outcomes4Me

Outcomes4Me provides an AI-driven platform that integrates NCCN Guidelines and presents those gui...

Boston, United States51–200Artificial Intelligence, Healthcare
Series BTotal funding$44.5MMay 2025
70
LinkSquares

LinkSquares provides an AI contract management platform for enterprise teams, combining lifecycle...

Boston, United States201–500Artificial Intelligence, Legal Tech
Series BTotal funding$40.0MJul 2021
71
Quris

AI-powered drug safety prediction platform using machine learning bio-platform to identify viable...

Boston, United States11–50Artificial Intelligence, Biotech
SeedTotal funding$37.0MDec 2022
72
Counsel Health

Counsel uses an AI-enabled, physician-supervised model to increase clinical capacity and help sha...

Boston, United States51–200Artificial Intelligence, Healthcare
Series ATotal funding$36.0MOct 2025
73
VerAI

VerAI Discoveries is an AI-driven mineral asset company that leverages its proprietary AI Discove...

Boston, United States11–50Artificial Intelligence, Climate Tech
Series BTotal funding$36.0MFeb 2025
74
Vizit

Agentic AI platform that scores, creates, and optimizes digital product and marketing content (im...

Boston, United States51–200Artificial Intelligence, E-Commerce
Series BTotal funding$35.0MOct 2024
75
AdeptID

Provides explainable talent-matching AI and APIs to staffing firms, ATS providers, and workforce ...

Boston, United States11–50Artificial Intelligence, HR Tech
Series ATotal funding$34.7MDec 2025