All Rankings

Top 100 Chicago Startups 2026

The most-funded startups headquartered in Chicago, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $15.0B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&cities=Chicago&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

26
LogicGate

Empowering businesses to transform disorganized risk and compliance processes into enterprise-gra...

Chicago, United States201–500Compliance
Series CTotal funding$154.0MNov 2022
27
Zarminali Pediatrics

Zarminali Pediatrics is a nationwide pediatric multispecialty group providing coordinated primary...

Chicago, United States51–200Life Sciences, Healthcare
Series ATotal funding$150.0MJan 2026
28
Hopscotch Primary Care

Primary care provider focused on expanding access in rural communities, with emphasis on senior p...

Chicago, United States201–500Healthcare
Series DTotal funding$141.3MAug 2026
29
Zing Health

Zing Health provides Medicare Advantage plans tailored for underserved seniors, addressing health...

Chicago, United States51–200Healthcare
Venture RoundTotal funding$140.0M
30
Vanqua Bio

Vanqua Bio is a Chicago biopharmaceutical company that discovers and develops next-generation med...

Chicago, United States11–50Biotech, Healthcare
Series BTotal funding$136.0MSep 2021
31
Evozyne

AI-native biotech company designing novel therapeutic proteins using generative AI to solve immun...

Chicago, United States51–200Artificial Intelligence, Biotech
Series BTotal funding$135.2MSep 2023
32
Fly.io

Run full stack apps close to your users.

Chicago, United States51–200Infrastructure
Series DTotal funding$132.0MJul 2026
33
ThreeKit

Threekit builds an AI sales agent that helps manufacturers quote complex products by connecting c...

Chicago, United States51–200E-Commerce, SaaS
Series BTotal funding$130.0MSep 2024
34
Provi

B2B marketplace connecting bars, restaurants, and retailers with distributors and suppliers to di...

Chicago, United States51–200Food & Beverage, Marketplace
Series CTotal funding$124.8MSep 2021
35
SpotHero

SpotHero is the leading parking reservation marketplace in North America, helping millions find, ...

Chicago, United States201–500Marketplace, Transportation
Series DTotal funding$117.1MAug 2019
36
Jungle Scout

Jungle Scout delivers Amazon intelligence and data analytics powering market trends, sales insigh...

Chicago, United States51–200E-Commerce, SaaS
Growth EquityTotal funding$110.0MMar 2021
37
Hallow

Catholic prayer and meditation app that guides users in prayer, scripture reading, and spiritual ...

Chicago, United States11–50Entertainment
Series CTotal funding$105.0MMay 2023
38
Freehand

Freehand provides AI teams that audit, resolve, and close work within guardrails customers define...

Chicago, United States51–200Artificial Intelligence, SaaS
Series BTotal funding$100.0MJul 2026
39
Litera

Litera is a legal technology platform offering AI-powered document drafting, review, and knowledg...

Chicago, United States1001–5000Artificial Intelligence, SaaS
Series BTotal funding$100.0MJun 2026
40
Nova Clean Energy

Nova Clean Energy develops and constructs large-scale wind, solar, and storage projects across th...

Chicago, United States11–50Climate Tech
Growth EquityTotal funding$100.0MJan 2025
41
HDVI

HDVI (High Definition Vehicle Insurance) provides data-driven commercial trucking insurance for s...

Chicago, United States51–200Fintech
Series CTotal funding$88.5MFeb 2025
42
Farmer's Fridge

Farmer's Fridge operates more than 2,000 smart Fridges stocking fresh meals and snacks at airport...

Chicago, United States201–500E-Commerce
Series ETotal funding$88.3MSep 2022
43
NOCD

NOCD is the leading telehealth provider for OCD treatment, connecting patients with licensed ther...

Chicago, United States51–200Digital Health, Healthcare
Series CTotal funding$84.2MFeb 2023
44
ThreeFlow

Provides a benefits placement system connecting insurance brokers and carriers to streamline quot...

Chicago, United States51–200Business Intelligence, Insurtech
Series CTotal funding$83.0MJan 2024
45
Mediafly

Mediafly provides revenue enablement software for complex organizations, combining seller engagem...

Chicago, United States201–500CRM, SaaS
Venture RoundTotal funding$80.0MAug 2023
46
The Mom Project

The Mom Project helps employers hire skilled mothers for contract, part-time, and full-time remot...

Chicago, United States51–200SaaS
Series CTotal funding$80.0MOct 2021
47
Syndio

Syndio Solutions is an HR Analytics company that focuses on promoting fairness in the workplace. ...

Chicago, United States51–200Analytics, HR Tech
Extension RoundTotal funding$79.8MMar 2022
48
Dscout

AI-powered experience research platform enabling teams to recruit participants, run studies, and ...

Chicago, United States201–500SaaS
Series CTotal funding$77.5MMar 2022
49
Semaphor

Semaphor is an agent-native business intelligence platform that serves internal BI and embedded c...

Chicago, United States1–10Artificial Intelligence, Data & Analytics
Venture RoundTotal funding$74.0MJan 2026
50
Fingerprint

Device intelligence platform providing highly accurate browser and mobile device fingerprinting A...

Chicago, United States51–200Cybersecurity, Developer Tools
Series CTotal funding$73.0MOct 2023