All Rankings

Top 100 Chicago Startups 2026

The most-funded startups headquartered in Chicago, ranked by total capital raised.

Known total funding for 100 of 100 ranked companies: $15.0B.

Showing top 100 matching companies · Ranked by total funding raised

Use company data through the API.
Example request
curl "https://indexed.vc/api/v1/companies?countries=United+States&cities=Chicago&operatingStatus=active&sort=total_funding_raised&order=desc&limit=100" -H "X-API-Key: YOUR_API_KEY"

The API has no company type filter, so public companies can appear; this list counts private companies only.

The API cannot leave out companies whose latest round is a grant, private equity or debt financing; this list does.

Data from Indexed.vcUpdated

Methodology: up to 100 active companies matching this list's filters are ordered by disclosed total funding in USD. Companies whose latest round is one of: Grant, Private Equity, Debt Financing are excluded. Totals include recorded grants and other qualifying funding, not just equity. Open a company profile for its funding summary and available detail. How this data is built.

76
Obie

Insurance and Risk Management for Landlords

Chicago, United States51–200Insurance, Real Estate
Series BTotal funding$39.0MMay 2023
77
Onna

Enterprise unstructured data management and eDiscovery platform; acquired by Reveal in 2024.

Chicago, United States501–1000Data & Analytics, Legal Tech
Series BTotal funding$38.0MJun 2020
78
CareMerge

Cloud-based platform that links clinical, wellness, and family communication for senior living co...

Chicago, United States11–50Healthcare, SaaS
Venture RoundTotal funding$37.2MOct 2024
79
Empirical Security

Threat discovery and exploit intelligence platform.

Chicago, United States11–50Cybersecurity
Series ATotal funding$37.0MJul 2026
80
HOPPR

Secure platform for refining and deploying AI models in medical imaging, accelerating AI developm...

Chicago, United States11–50Artificial Intelligence, Healthcare
Series ATotal funding$34.5MJun 2025
81
Vinyl Equity

Next-generation cloud-native transfer agent platform connecting issuers, shareholders, and servic...

Chicago, United States1–10Fintech, SaaS
Series ATotal funding$31.5MJun 2026
82
Insureon
Chicago, United States51–200Insurance, Insurtech
Series BTotal funding$31.0MOct 2015
83
Synapticure

Synapticure delivers virtual care that closes unmet gaps for individuals and families living with...

Chicago, United States11–50Digital Health, Healthcare
Series ATotal funding$31.0MNov 2024
84
LuxCreo

LuxCreo provides automated dental 3D printing solutions for clear aligners and dental appliances,...

Chicago, United States51–200Healthcare
Venture RoundTotal funding$30.0MOct 2025
85
PriceLabs

Dynamic pricing and revenue management software for short-term rental hosts and property managers...

Chicago, United States51–200SaaS
Growth EquityTotal funding$30.0MJul 2022
86
Syntax Bio

Develops a CRISPR-based platform to program and accelerate stem cell differentiation, enabling sc...

Chicago, United States1–10Biotech, Life Sciences
SeedTotal funding$29.4MSep 2024
87
PRENOSIS INC

R&D company with 7 SBIR/STTR awards from Department of Health and Human Services, National Scienc...

Chicago, United States11–50Artificial Intelligence, Biotech
Series ATotal funding$29.0MJan 2026
88
Aclaimant

Risk management and claims management SaaS platform for enterprise safety and compliance.

Chicago, United States11–50SaaS
Series BTotal funding$27.9MJan 2022
89
Inventables

Desktop CNC machine and carving software company empowering makers, educators, and small business...

Chicago, United States11–50SaaS
Series CTotal funding$26.5MJul 2019
90
CancerIQ

Digital health platform helping hospitals scale precision cancer prevention through genetic risk ...

Chicago, United States51–200Healthcare, SaaS
Growth EquityTotal funding$26.3MAug 2024
91
Benchprep

Learning platform that delivers interactive and personalized courses on web, mobile and tablets i...

Chicago, United States51–200SaaS
Series CTotal funding$26.0MJan 2019
92
Aeropay

Aeropay is a financial technology company providing account-to-account payment solutions for fast...

Chicago, United States51–200Fintech
Series BTotal funding$25.0MMay 2024
93
Coinflow

Crypto payment infrastructure enabling on/off ramp and checkout solutions for Web3 applications.

Chicago, United States11–50Crypto & Web3, Fintech
Series ATotal funding$25.0MJul 2022
94
Klover

Helps millions of people cover small dollar needs in exchange for anonymized transactional data

Chicago, United States51–200Fintech
Series BTotal funding$25.0MNov 2022
95
Logiwa
Chicago, United States51–200E-Commerce, Retail
Series ATotal funding$24.9MApr 2021
96
Dimension Bio

Chicago-based biotechnology company developing implantable tissue therapeutics to restore organ f...

Chicago, United States1–10Biotech, Healthcare
Series ATotal funding$23.2MJan 2024
97
86 Repairs

86 Repairs is a tech-enabled repair and maintenance management platform built for the restaurant ...

Chicago, United States51–200SaaS
Series ATotal funding$22.5MJan 2022
98
Built In

Built In is a top destination for highly skilled professionals around the world. Our platform fea...

Chicago, United States51–200HR Tech, Media
Series CTotal funding$22.0MJul 2019
99
Songfinch

Platform connecting customers with professional musicians who create personalized commissioned so...

Chicago, United States11–50Audio, Creator Economy
Series ATotal funding$22.0MSep 2022
100
Cohesion

Smart building technology company offering software, AI solutions, and advisory services that int...

Chicago, United States11–50SaaS
Series ATotal funding$21.5MNov 2021