Fifty Years is a Venture Capital based in San Francisco.

How many investments has Fifty Years made?

Fifty Years has made 66 disclosed investments.

How much does Fifty Years manage?

Fifty Years manages $200.0M in assets.

What companies has Fifty Years invested in?

Fifty Years's portfolio includes Avail Bio, Lygos, UPSIDE Foods, Valence Labs, BioRender, Invitae.

Fifty Years

Q: What does Fifty Years invest in?

Fifty Years invests in Biotech, Climate Tech, Deep Tech, Healthcare, Life Sciences Pre-Seed, Seed companies.

Venture Capital

Pre-seed and seed venture capital firm that exclusively backs founders using technology to solve civilization-scale problems like climate change, disease, and food systems.

San Francisco, United States · 66+ investments · 81 portfolio companies

Website

Pre-Seed

Seed

Biotech

Climate Tech

Deep Tech

Healthcare

Life Sciences

Headquarters: San Francisco, United States
Founded: 2015
Website: fiftyyears.com
AUM: $200.0M

Portfolio Companies: 81
Total Investments: 66
Last Investment: Feb 2026
Geographic Focus: Europe, North America, United States

Investment Thesis

Fifty Years backs pre-seed and seed founders using technology to solve humanity's biggest challenges — climate, health, food, connectivity — while building massively profitable businesses.

Fifty Years is a Venture Capital firm based in San Francisco, United States. It has made 66 investments in Biotech and Climate Tech, including Avail Bio, Lygos and UPSIDE Foods.