Ligo Bioscience

Ligo Biosciences is a San Francisco-based biotechnology startup building next-generation computational tools to manipulate chemistry and biology, with an initial focus on enzyme design. The company develops deep-learning models that allow scientific agents to search enzyme space deliberately — discovering new catalysts, new biological functions, and novel ways to intervene in biology — and is known for releasing an open-source implementation of AlphaFold3. Ligo's customers and collaborators are researchers and biotech organizations seeking to accelerate chemical manufacturing and biological discovery; their enzyme design tools aim to slash the cost and time of developing new industrial and therapeutic enzymes. Founded in 2024 and backed by Y Combinator, the team spans biology, chemistry, mathematics, and computer science.