Top Series A Companies in the US 2026

Series A companies headquartered in the United States — the most promising US growth-stage startups that have cleared the first major institutional bar.

As of June 2026, these 100 companies have raised $29.9B in combined funding.

Showing top 100 of 2,767 matching companies · Ranked by total funding raised · Updated Jun 2026

51

Subscription-based activewear retailer selling men's and women's athletic apparel, footwear, and ...

El Segundo, United States1001–5000E-Commerce, Fashion, Beauty

Series A·$166.8M·Jun 2025

52

NewLeaf Symbiotics

Biological technology provider and global leader in PPFM microbials for modern production agricul...

United States11–50Agtech, Biotech

Series A·$161.0M·Jun 2026

53

August Bioservices

End-to-end CDMO for life sciences companies

United States51–200Biotech

Series A·$158.6M·Jun 2026

54

Zarminali Pediatrics

Zarminali Pediatrics is a nationwide pediatric multispecialty group providing coordinated primary...

Chicago, United States51–200Life Sciences, Healthcare

Series A·$150.0M·Jan 2026

55

Shape Therapeutics

A development stage biotechnology company based in Seattle WA and San Diego CA that is establishi...

Seattle, United States51–200Artificial Intelligence, Biotech

Series A·$147.5M

56

Biotechnology company pioneering cardio-immunology, developing novel immunotherapies targeting th...

Palo Alto, United States11–50Biotech

Series A·$145.0M·Jun 2023

57

We manage people's wealth

New York, United States11–50Fintech, SaaS

Series A·$144.5M·Aug 2025

58

AI preventative health clinic for seniors

San Francisco, United States11–50Healthcare

Series A·$144.0M·Mar 2026

59

Candy Fanatics (fka Candy Digital)

Candy is a new digital asset content company building an innovative NFT ecosystem that will chang...

New York, United States51–200Crypto & Web3

Series A·$138.4M·Jan 2023

60

Gene-editing startup developing treatments for alpha-1 antitrypsin deficiency (AATD) and other ge...

San Diego, United States1–10Biotech, Healthcare

Series A·$138.0M·Jun 2026

61

Jasper is a leader in creating content using Artificial Intelligence

Austin, United States51–200Artificial Intelligence, Conversational AI

Series A·$137.0M·Oct 2022

62

Independent music venue investment and services platform supporting indie venues and promoters; r...

Los Angeles, United States11–50Media, Events

Series A·$135.0M·Apr 2022

63

Integrated photonics company developing silicon photonics platform for high-speed optical connect...

Santa Barbara, United States51–200Developer Tools

Series A·$134.0M·Apr 2026

64

Leal Therapeutics

Biotechnology company developing novel neuro-metabolic therapies for CNS disorders including neur...

Worcester, United StatesBiotech, Healthcare

Series A·$133.5M·Aug 2025

65

Gilgamesh Pharmaceuticals

Gilgamesh Pharmaceuticals, a Clinical stage biotechnology company…

New York, United States11–50Healthcare, Mental Health

Series A·$126.0M·Mar 2026

66

AI networking company developing intelligent network infrastructure.

Palo Alto, United States11–50Artificial Intelligence, Infrastructure

Series A·$125.0M·Apr 2026

67

Boston AI startup providing verifiable, neuro-symbolic automated code translation for defense, au...

Boston, United StatesArtificial Intelligence, Developer Tools

Series A·$125.0M·Nov 2025

68

Coultreon Biopharma

Clinical-stage biopharmaceutical company.

Leuven, United States11–50Biotech

Series A·$125.0M·Apr 2026

69

Nested Therapeutics

Precision oncology biotech identifying novel cancer driver mutations to expand targeted therapy o...

Cambridge, United States11–50Biotech, Healthcare

Series A·$125.0M·Oct 2022

70

OnCusp Therapeutics

Clinical-stage biopharma developing targeted oncology therapeutics and ADCs to advance treatments...

Princeton, United States11–50Biotech, Healthcare

Series A·$125.0M·Jan 2024

71

Workplace learning technology vendor offering TalentLMS and eFront platforms serving 70,000+ team...

San Francisco, United States201–500EdTech, SaaS

Series A·$122.5M·Jan 2017

72

Full-stack AI cloud platform for inference, fine-tuning, and GPU cluster workloads.

United StatesArtificial Intelligence, Cloud

Series A·$122.5M·Nov 2023

73

Intelligently designed precision therapies, including a novel KIT inhibitor being developed for GIST

Cambridge, United States11–50Healthcare

Series A·$122.0M·Aug 2022

74

Merida Biosciences

Merida Biosciences develops therapeutics targeting autoimmune and allergic diseases.

United StatesBiotech, Healthcare

Series A·$121.0M·Apr 2025

75

The Boring Company builds safe, fast, low-cost transportation and utility tunnels, founded by Elo...

Bastrop, United States201–500Construction, Infrastructure

Series A·$120.0M·Jul 2019

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