Top Series A Companies in the US 2026

Series A companies headquartered in the United States — the most promising US growth-stage startups that have cleared the first major institutional bar.

As of June 2026, these 100 companies have raised $29.9B in combined funding.

Showing top 100 of 2,767 matching companies · Ranked by total funding raised · Updated Jun 2026

26

Mathematical superintelligence platform

Palo Alto, United States11–50Artificial Intelligence

Series A·$264.0M·Mar 2026

27

AI lab building NEXUS, a Large Tabular Model purpose-built for structured enterprise data, enabli...

San Francisco, United States11–50Artificial Intelligence, Data & Analytics

Series A·$255.0M·Feb 2026

28

AI research company developing advanced language models and AI systems.

San Francisco, United States11–50Artificial Intelligence

Series A·$255.0M·Feb 2026

29

Monad’s platform unites security data silos and builds effective security and compliance workflows.

San Francisco Bay Area, United States51–200Crypto & Web3, Compliance

Series A·$244.0M·Apr 2024

30

Anti-ransomware cybersecurity platform combining AI-driven endpoint protection, key capture for a...

Austin, United States201–500Cybersecurity

Series A·$232.0M·Mar 2026

31

A reimagined workspace with AI at its core

San Francisco, United States1–10Artificial Intelligence

Series A·$203.0M·Jan 2023

32

Web3 gaming company bringing free-to-play experiences to blockchain by mobile gaming veterans.

United States51–200Blockchain & Crypto, Gaming

Series A·$201.0M·Aug 2022

33

Airnexis Therapeutics

Clinical-stage biotech developing novel therapeutics for pulmonary diseases, including dual PDE3/...

Palo Alto, United States11–50Biotech, Healthcare

Series A·$200.0M·Jan 2026

34

CNS-focused drug developer targeting neurological, cardiometabolic, and ophthalmic diseases with ...

San Francisco, United States11–50Biotech, Healthcare

Series A·$200.0M·Jan 2025

35

Yarrow Biosciences

Clinical-stage biotechnology company developing first-in-class anti-TSHR antibody therapies for a...

New York, United States1–10Biotech, Healthcare

Series A·$200.0M·Dec 2025

36

Alveus Therapeutics

Philadelphia early-stage venture

Philadelphia, United States11–50Biotech

Series A·$197.0M·Mar 2026

37

RoadRunner Recycling is a technology-enabled marketplace for commercial recycling and waste removal.

Pittsburgh, United States501–1000Climate Tech, Clean Tech

Series A·$194.0M·May 2026

38

Aera Therapeutics

Biotechnology company developing next-generation genetic medicines using a proprietary protein na...

Boston, United States51–200Biotech, Drug Discovery

Series A·$193.0M·Feb 2023

39

Powered by the company's own foundational LLM, Character.AI is a platform that gives consumers ac...

Menlo Park, United States201–500Artificial Intelligence, Entertainment

Series A·$193.0M·Mar 2023

40

North America's leading resident-centric technology-powered operating platform for residential re...

New York, United States201–500SaaS

Series A·$190.0M·Jan 2026

41

Fabric is a healthcare technology company offering an AI-powered care enablement platform that un...

New York, United States201–500Artificial Intelligence, Healthcare

Series A·$190.0M·Feb 2024

42

Callio Therapeutics

Callio Therapeutics is developing next‐generation dual‐payload antibody drug conjugates (ADCs) fo...

Seattle, United States1–10Biotech, Oncology

Series A·$187.0M·Mar 2025

43

Biotech company focused on cellular therapeutics.

United StatesBiotech

Series A·$185.0M·Nov 2025

44

Fertility and family-building benefits company that operates a national network of fertility clin...

New York, United States501–1000Femtech, Healthcare

Series A·$184.0M

45

Cytospire Therapeutics

Biotech developing targeted protein conjugates for oncology.

London, United States11–50Biotech, Healthcare

Series A·$182.0M·May 2026

46

Standard Nuclear

Manufacturer of TRISO nuclear fuel for advanced reactors, supplying utilities and reactor develop...

Oak Ridge, United States11–50Clean Energy, Nuclear Energy

Series A·$182.0M·Jan 2026

47

Employee financial wellness platform offering AI-powered budgeting, investment tools, tax plannin...

San Francisco, United States51–200Financial Services, Fintech

Series A·$179.0M·Mar 2026

48

Antares Therapeutics

Antares Therapeutics is a biotechnology company developing first-in-class precision medicines for...

Boston, United States11–50Biotech, Healthcare

Series A·$177.0M·Jun 2025

49

Lightspark is created to explore, build and extend the capabilities and utility of Bitcoin.

Los Angeles, United States51–200Crypto & Web3

Series A·$175.0M·May 2022

50

Home food recycler that dries and grinds kitchen scraps into odorless grounds repurposed as chick...

San Bruno, United States51–200Climate Tech

Series A·$170.0M·Aug 2024

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