Protocol Labs
Corporate VC
We invest in Web3 and new computing platforms
San Francisco, United States · 25+ investments · 21 portfolio companies
Seed
Early Stage
Artificial Intelligence
Crypto & Web3
Decentralized Computing
Biotech
Deep Tech
- Headquarters
- San Francisco, United States
- Founded
- 2014
- Website
- protocol.ai
- Portfolio Companies
- 21
- Total Investments
- 25
- Last Investment
- Dec 2025
- Geographic Focus
- Global
Investment Thesis
We invest in Web3 and new computing platforms
Protocol Labs is a Corporate VC firm based in San Francisco, United States. It has made 25 investments in Artificial Intelligence and Crypto & Web3, including Seal Storage, Spice AI and DeSci Labs.
Portfolio21
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Co-investors24
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24 co-investors across 42 shared portfolio companies — who they back alongside, and how often they lead.
Venture Capital ×19 · Accelerator ×2 · Hedge Fund ×1 · 33 shared rounds
Investment History
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