Lewis & Clark Ventures

Venture Capital

Lewis & Clark Ventures is a Venture Capital firm based in St. Louis, United States.

Lewis & Clark Ventures is an early stage venture firm managed by former founders and operators. The firm invests in B2B software companies from late seed through Series A and provides founders with tools, guidance, and resources to help them succeed.

Seed
Early Stage
Headquarters
St. Louis, United States
Founded
2015
Portfolio Companies
9
Total Investments
10
Last Investment
Oct 2025
Geographic Focus
United States, Midwest
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Indexed holds 9 portfolio companies and 10 funding rounds for this investor. The full record is or through the API.

Investment Thesis

We invest in B2B SaaS with $1M+ ARR

It was founded in 2015. It has made 10 investments. Its portfolio includes Amper, Plastomics and Splento.

Portfolio9

Co-investors24

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24 co-investors across 24 shared portfolio companies — who they back alongside, and how often they lead.

Venture Capital ×20 · Angel Group ×1 · Corporate VC ×1 · 21 shared rounds

Investment History

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Lewis & Clark Ventures on Indexed.vc
<a href="https://indexed.vc/investors/lewis-clark-ventures"><img src="https://indexed.vc/api/badge/investor/lewis-clark-ventures" alt="Lewis & Clark Ventures on Indexed.vc" width="260" height="76" /></a>