Jefferson River Capital
Venture Capital
Single-family office for Hamilton "Tony" James allocating long-term capital across private equity, real assets, life sciences, and venture opportunities.
New York · 2+ investments
Early Stage
Growth
Late Stage
Healthcare
Life Sciences
- Headquarters
- New York
- Founded
- 2016
- Website
- jeffersonlifesciences.com
- AUM
- $2.5B
- Total Investments
- 2
- Last Investment
- Feb 2026
- Geographic Focus
- United States
Investment Thesis
Acts as a long-term co-investor across private equity, life sciences, and venture-stage deals, pairing patient family-office capital with institutional and strategic partners.
Jefferson River Capital is a Venture Capital firm based in New York. It has made 2 investments in Healthcare and Life Sciences.
Investment History
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