Jefferson River Capital

Venture Capital

Single-family office for Hamilton "Tony" James allocating long-term capital across private equity, real assets, life sciences, and venture opportunities.

New York · 2+ investments · 2 portfolio companies

Early Stage
Growth
Late Stage
Healthcare
Life Sciences
Headquarters
New York
Founded
2016
AUM
$2.5B
Portfolio Companies
2
Total Investments
2
Last Investment
Feb 2026
Geographic Focus
United States

Investment Thesis

Acts as a long-term co-investor across private equity, life sciences, and venture-stage deals, pairing patient family-office capital with institutional and strategic partners.

Jefferson River Capital is a Venture Capital firm based in New York. It has made 2 investments, including Coral Care and Augmodo. Focus areas include Healthcare and Life Sciences.

Portfolio2

Co-investors13

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13 co-investors across 13 shared portfolio companies — who they back alongside, and how often they lead.

Venture Capital ×13 · 9 shared rounds

Investment History

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