Big Brain Holdings

Venture Capital

Big Brain Holdings is a Venture Capital firm based in Los Angeles, United States.

Crypto-exclusive multi-strategy VC backing cypherpunk-rooted founders in crypto, DeFi, AI, robotics, and deeptech.

Pre-Seed
Seed
Early Stage
Artificial Intelligence
Crypto & Web3
Robotics
Headquarters
Los Angeles, United States
Founded
2021
Portfolio Companies
19
Total Investments
19
Last Investment
Mar 2026
Geographic Focus
Global
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Indexed holds 19 portfolio companies and 19 funding rounds for this investor. The full record is or through the API.

Investment Thesis

Thesis-driven crypto-exclusive fund backing radical founders rooted in cypherpunk values.

It was founded in 2021. It has made 19 investments. Its portfolio includes Shardeum, Grass and M10. Focus areas include Artificial Intelligence and Crypto & Web3.

Portfolio19

Co-investors24

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24 co-investors across 40 shared portfolio companies — who they back alongside, and how often they lead.

Venture Capital ×19 · Accelerator ×3 · Corporate VC ×2 · 32 shared rounds

Investment History

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Big Brain Holdings on Indexed.vc
<a href="https://indexed.vc/investors/big-brain-holdings"><img src="https://indexed.vc/api/badge/investor/big-brain-holdings" alt="Big Brain Holdings on Indexed.vc" width="260" height="76" /></a>