Reneo Pharmaceuticals was a clinical-stage biopharmaceutical company founded in 2014 in San Diego, California, focused on the development of therapies for patients with rare genetic mitochondrial diseases. Reneo's lead program, REN001 (a PPARdelta agonist), targeted primary mitochondrial myopathy. The company went public on Nasdaq in April 2021 under the symbol RPHM. Following a Phase 2b clinical trial failure in May 2024, Reneo merged with OnKure Therapeutics, closing the merger in October 2024.
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