PICCOLO MEDICAL, INC.

Piccolo Medical develops FDA-cleared catheter navigation and tip confirmation technologies for peripherally inserted central catheter (PICC) placement. Its flagship product, the PM2+ System, uses ionic dilution technology — which leverages blood flow to guide catheter navigation from the insertion site to the superior vena cava — and is 510(k) cleared as an alternative to chest X-ray for bedside PICC tip confirmation in adult, pediatric, and neonatal patients. The company also offers ECGuide, an intravascular ECG-based tip confirmation system that has demonstrated improved placement accuracy and reduced complication rates. In 2025, Spectrum Vascular acquired the company.