Deep Principle

Deep Principle is an AI-for-science company that accelerates chemical reaction modeling and materials discovery using machine learning. Founded by MIT-trained researchers including Dr. Haojun Jia and Dr. Chenru Duan, the company has developed ReactiveAI, a computational platform that generates novel chemical reactions and materials with high accuracy. Deep Principle's technology reduces the time for identifying reaction transition states from hours to minutes, enables high-throughput DFT calculations at experimental accuracy, and accelerates target materials retrieval by orders of magnitude. The company has received backing from Gaorong Capital, Vertex Ventures China, and DP Technology, and its work is grounded in peer-reviewed research published in Nature Computational Science, JACS Au, and the Journal of Chemical Theory and Computation.