CALDRE
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CALDRE was founded in 2021 and is headquartered in Bern, Switzerland.
About
CALDRE is a Swiss biotechnology spinout developing precise, liver-directed RNA therapeutics for cholestatic and fibrotic diseases. Its lead program, ClagalsiR, targets claudin-3 with a liver-specific GalNAc-siRNA intended to selectively open the paracellular barrier between liver hepatocytes. Preclinical models indicate that claudin-3 inhibition increases bile water content and lowers bile toxicity, tissue necrosis, and fibrosis, supporting the company’s mission to prevent liver transplantation.
Summary
CALDRE is a Biotech company based in Bern, Switzerland, founded in 2021.
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